Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 10/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627067 | 0.88 | KDM4E (0.46) | GPR119ACKR3PRMT5JAK2KDM4E | |
| SCHEMBL625492 | 0.86 | NAMPT (0.39) | NAMPTGPR119CYP2C9ACKR3 | |
| SCHEMBL627340 | 0.82 | NAMPT (0.49) | NAMPTGPR119CYP2C9ACKR3 | |
| SCHEMBL624454 | 0.79 | PIM1 (0.45) | NAMPTGPR119PRMT5 | |
| SCHEMBL627015 | 0.79 | ACKR3 (0.61) | ACKR3 | |
| SCHEMBL628407 | 0.77 | CYP11B2 (0.44) | NAMPTGPR119JAK2JAK1 | |
| SCHEMBL627884 | 0.77 | CCNA2 (0.50) | GPR119ACKR3PRMT5JAK1MAPT | |
| SCHEMBL627267 | 0.76 | CYP11B2 (0.41) | — | |
| SCHEMBL627422 | 0.74 | RET (0.42) | CYP2C9 | |
| SCHEMBL2257064 | 0.72 | MKNK1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |