Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627267 | 0.93 | CYP11B2 (0.41) | CYP11B2RETACACBCYP3A4SCD5 | |
| SCHEMBL627265 | 0.90 | CKS1B (0.41) | GPR119 | |
| SCHEMBL627422 | 0.90 | RET (0.42) | CYP11B2RETACACBCYP3A4SCD5 | |
| SCHEMBL625492 | 0.81 | NAMPT (0.39) | ACACBGPR119NAMPT | |
| SCHEMBL627207 | 0.81 | OPRM1 (0.39) | GPR119 | |
| SCHEMBL628406 | 0.79 | CYP11B2 (0.44) | CYP11B2RETACACBCYP3A4GPR119 | |
| SCHEMBL627513 | 0.78 | OPRM1 (0.37) | GPR119 | |
| SCHEMBL627341 | 0.77 | NAMPT (0.47) | GPR119NAMPTJAK2JAK1 | |
| SCHEMBL625512 | 0.76 | THRB (0.44) | CYP11B2SCD5 | |
| SCHEMBL627226 | 0.75 | CKS1B (0.46) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |