Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 13/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | DLK1 | P80370 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627020 | 0.94 | RET (0.40) | RETPIK3CAMAP3K12PIK3R1 | |
| SCHEMBL625422 | 0.93 | PIK3CA (0.42) | RETPIK3CAMAP3K12 | |
| SCHEMBL626123 | 0.92 | RET (0.43) | RETPIK3CAMAP3K12PIK3R1 | |
| SCHEMBL627431 | 0.87 | PIK3CA (0.48) | PIK3CA | |
| SCHEMBL625408 | 0.86 | MAP4K1 (0.39) | PIK3CAMAP3K12DLK1MAP4K1 | |
| SCHEMBL627309 | 0.85 | MAP3K12 (0.46) | PIK3CAMAP3K12DLK1MAP4K1 | |
| SCHEMBL624439 | 0.83 | MAP3K12 (0.41) | PIK3CAMAP3K12DLK1 | |
| SCHEMBL626246 | 0.83 | MAP3K12 (0.40) | PIK3CAMAP3K12DLK1 | |
| SCHEMBL627019 | 0.82 | PIK3CA (0.47) | RETPIK3CAMAP3K12 | |
| SCHEMBL625132 | 0.81 | CKS1B (0.42) | RETPIK3CAMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |