Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 6/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627432 | 0.93 | RET (0.40) | PIK3CAMAP3K12RET | |
| SCHEMBL627020 | 0.90 | RET (0.40) | PIK3CAF2RL3MAP3K12RET | |
| SCHEMBL626246 | 0.90 | MAP3K12 (0.40) | PIK3CAMAP3K12 | |
| SCHEMBL627309 | 0.89 | MAP3K12 (0.46) | PIK3CAMAP3K12 | |
| SCHEMBL626123 | 0.88 | RET (0.43) | PIK3CAMAP3K12RET | |
| SCHEMBL625421 | 0.86 | PIK3CA (0.52) | PIK3CAMAP3K12MAP4K4 | |
| SCHEMBL625132 | 0.84 | CKS1B (0.42) | PIK3CAMAP3K12RETMAPTTHRB | |
| SCHEMBL625128 | 0.84 | CCNA2 (0.46) | PIK3CAMAP3K12 | |
| SCHEMBL624922 | 0.83 | PIK3CA (0.42) | PIK3CAMAP3K12 | |
| SCHEMBL625408 | 0.83 | MAP4K1 (0.39) | PIK3CAMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |