Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.35 |
| ▸ | THRA | P10827 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640592 | 0.88 | THRB (0.38) | THRBTHRAALDH1A1KDM4EHPGD | |
| SCHEMBL6275290 | 0.80 | PTGS1 (0.40) | THRBTHRAALDH1A1KDM4EPTGDR2 | |
| SCHEMBL6269426 | 0.78 | THRA (0.56) | THRBTHRA | |
| SCHEMBL6273741 | 0.76 | THRB (0.42) | THRBTHRAALDH1A1KDM4EPTGS1 | |
| SCHEMBL1640505 | 0.76 | THRB (0.47) | THRBTHRAPTGS1PTGS2GAA | |
| SCHEMBL6854726 | 0.74 | THRB (0.43) | THRBTHRAALDH1A1CNR1GAA | |
| SCHEMBL4961754 | 0.74 | GAA (0.41) | THRBTHRAALDH1A1POLBCNR1 | |
| SCHEMBL7592718 | 0.74 | SOS1 (0.47) | THRBTHRAALDH1A1POLBPTGS1 | |
| SCHEMBL6853009 | 0.73 | THRA (0.45) | THRBTHRAHPGDHIF1APOLB | |
| SCHEMBL6861552 | 0.73 | THRB (0.40) | THRBTHRAALDH1A1KDM4ECNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |