Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6278822 | 0.85 | RXFP1 (0.45) | NPC1RAB9AMAPTKDM4E | |
| SCHEMBL20413782 | 0.84 | ALDH1A1 (0.47) | NPC1RAB9ATP53MAPTGRM1 | |
| SCHEMBL6205474 | 0.82 | NPC1 (0.44) | NPC1RAB9AATMTP53MAPT | |
| SCHEMBL6237143 | 0.80 | CYP11B2 (0.48) | NPC1RAB9AMAPTGRM1KMT2A | |
| SCHEMBL6282717 | 0.80 | GSK3B (0.44) | NPBWR1MCHR1FLT3RXRA | |
| SCHEMBL6225827 | 0.80 | NPBWR1 (0.39) | NPC1RAB9ATP53MAPTNPBWR1 | |
| SCHEMBL30032844 | 0.73 | HPGD (0.54) | NPC1RAB9AATMGRM1NPBWR1 | |
| SCHEMBL4136494 | 0.70 | NPC1 (0.75) | NPC1RAB9AATMMAPTGRM1 | |
| Hydrochloric Acid SCHEMBL4129456 | 0.69 | NPC1 (0.73) | NPC1RAB9AATMMAPTGRM1 | |
| SCHEMBL6224500 | 0.69 | MAPT (0.65) | TP53MAPTHPGDKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |