Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6390136 | 0.83 | ALDH1A1 (0.48) | NPC1RAB9AKMT2ASMN1; SMN2TP53 | |
| SCHEMBL6276508 | 0.82 | NPC1 (0.46) | NPC1RAB9AATMPKMKMT2A | |
| SCHEMBL6274665 | 0.79 | CCR1 (0.36) | NPC1RAB9APKMKMT2ASMN1; SMN2 | |
| SCHEMBL6253146 | 0.77 | GSK3B (0.40) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL6278086 | 0.77 | GSK3B (0.49) | NPC1RAB9AKMT2ASMN1; SMN2TP53 | |
| SCHEMBL6277293 | 0.75 | XDH (0.43) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| SCHEMBL6237291 | 0.70 | CYP17A1 (0.46) | NPC1RAB9ATP53MAPTLMNA | |
| SCHEMBL6204905 | 0.70 | MAPT (0.71) | KMT2ATP53MAPTLMNAHPGD | |
| SCHEMBL6278822 | 0.69 | RXFP1 (0.45) | NPC1RAB9AMAPT | |
| SCHEMBL6237563 | 0.68 | GSK3B (0.43) | PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |