SCHEMBL627763

SCHEMBL627763

N#Cc1ccccc1-c1ccc2nc[nH]c2c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
QPCT Q16769 5/20 0.62
QPCTL Q9NXS2 3/20 0.62
TRPA1 O75762 1/20 0.51
CYP1A2 P05177 5/20 0.49
CYP3A4 P08684 5/20 0.49
ALDH1A1 P00352 4/20 0.49
HSD17B10 Q99714 4/20 0.49
HPGD P15428 3/20 0.49
CLK4 Q9HAZ1 3/20 0.49
MAPK1 P28482 2/20 0.49
ALOX5AP P20292 3/20 0.47
FEN1 P39748 3/20 0.47
KDM4E B2RXH2 2/20 0.47
NPC1 O15118 1/20 0.47
TP53 P04637 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
PRKCI P41743 1/20 0.47
LMNA P02545 2/20 0.46
MEN1 O00255 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30799073 0.88 TRPA1 (0.55) QPCTQPCTLTRPA1CYP1A2CYP3A4
SCHEMBL627762 0.88 TRPA1 (0.55) QPCTQPCTLTRPA1CYP1A2CYP3A4
Benzimidazole SCHEMBL834184 0.82 ESR2 (0.45) QPCTQPCTLTRPA1CYP1A2CYP3A4
SCHEMBL28294110 0.77 QPCTL (1.00) QPCTQPCTLALDH1A1HPGDALOX5AP
SCHEMBL7021611 0.75 RAB9A (0.56) TRPA1CYP1A2CYP3A4ALDH1A1HSD17B10
SCHEMBL28292522 0.75 QPCT (0.53) QPCTQPCTLALDH1A1HPGDKDM4E
SCHEMBL8634290 0.75 QPCT (0.68) QPCTQPCTLCYP3A4ALDH1A1HPGD
SCHEMBL27824937 0.75 QPCT (0.64) QPCTQPCTLALDH1A1HPGDALOX5AP
SCHEMBL2462345 0.74 QPCT (0.68) QPCTQPCTLALDH1A1HPGDKDM4E
SCHEMBL21363857 0.73 ADORA2A (0.60) QPCTQPCTLCLK4ALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2603079-A1 POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 Merck Sharp & Dohme Corp. (US) 2013-06-19 EP disclosed
WO-2012021382-A1 POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 MERCK SHARP & DOHME CORP. (US) 2012-02-16 WO disclosed
EP-0574174-B1 Angiotensin II antagonists LILLY CO ELI (US) 2003-08-13 EP disclosed
US-5693633-A Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1997-12-02 US disclosed
US-5612360-A AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS ELI LILLY AND COMPANY (US) 1997-03-18 US disclosed
US-5569768-A USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY ELI LILLY AND COMPANY (US) 1996-10-29 US disclosed
US-5556981-A Angiotensin II antagonist intermediates ELI LILLY AND COMPANY (US) 1996-09-17 US disclosed
EP-0574174-A2 Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1993-12-15 EP disclosed