Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.50 |
| ▸ | QPCT | Q16769 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6286767 | 0.92 | CDK2 (0.48) | ALDH1A1ROCK2ROCK1KMT2AGAA | |
| SCHEMBL6288017 | 0.88 | SMN1; SMN2 (0.52) | ALDH1A1ROCK2ROCK1CDK2CDK5 | |
| SCHEMBL6278437 | 0.85 | GSK3B (0.66) | ALDH1A1ROCK2ROCK1KMT2AMEN1 | |
| SCHEMBL5836044 | 0.84 | LMNA (0.67) | ALDH1A1KMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL6285587 | 0.83 | ATG4B (0.53) | ALDH1A1ROCK2ROCK1CDK2CDK5 | |
| SCHEMBL6282609 | 0.83 | ROCK2 (0.52) | ALDH1A1ROCK2KMT2ACDK2CDK5 | |
| SCHEMBL6282475 | 0.82 | CDK5 (0.52) | ALDH1A1ROCK2ROCK1MAPK1CDK2 | |
| SCHEMBL6278436 | 0.82 | CDK2 (0.52) | ALDH1A1CDK2CDK5CCNE1ATG4B | |
| SCHEMBL6282768 | 0.82 | CDK2 (0.64) | ALDH1A1KMT2AGAAMEN1CYP1A2 | |
| SCHEMBL6279197 | 0.81 | CCNE1 (0.57) | ALDH1A1ROCK2ROCK1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040157827-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PEVARELLO PAOLO (IT) | 2004-08-12 | — | — | US | claimed |
| US-20030187040-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2003-10-02 | — | — | US | claimed |
| US-6863647-B2 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2005-03-08 | — | — | US | disclosed |
| US-20040157827-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PEVARELLO PAOLO (IT) | 2004-08-12 | — | — | US | disclosed |
| US-20030187040-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187040-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | UCK2, ULK3, CDK2 | ALDH1A1 903/4885ROCK2 1685/4885ROCK1 1771/4885 |
| US-20040157827-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | UCK2, ULK3, CDK2 | ALDH1A1 903/4885ROCK2 1685/4885ROCK1 1771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.