SCHEMBL6283010

SCHEMBL6283010

CC(C)Oc1cccc(-n2c(NN)nc3ncccc3c2=O)c1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 1/20 0.47
PDE10A Q9Y233 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6308294 0.84 CCKBR (0.63) CCKBR
SCHEMBL6278508 0.75 LOXL3 (0.65)
SCHEMBL6278493 0.71 SMN1; SMN2 (0.70)
SCHEMBL8502010 0.71 SMN1; SMN2 (0.56) CCKBR
SCHEMBL8503645 0.69 SMN1; SMN2 (0.56) CCKBR
SCHEMBL618001 0.65 ALDH1A1 (0.45) PDE10A
SCHEMBL17199822 0.65 KDM4E (0.50) CCKBR
SCHEMBL6281843 0.65 SMN1; SMN2 (0.57)
SCHEMBL6280169 0.65 KDM4E (0.57)
SCHEMBL6283903 0.65 PDE7A (0.63)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6897213-B1 Heterocycles as cholecystokinin (CCK) ligands WARNER-LAMBERT COMPANY (US) 2005-05-24 US disclosed