Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | ATP4A | P20648 | 3/20 | 0.49 |
| ▸ | ATP4B | P51164 | 3/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280484 | 0.91 | ATP4A (0.47) | GAANPC1RAB9AGFERATP4A | |
| SCHEMBL6281999 | 0.88 | ATP4A (0.59) | ATP4AATP4BPSEN1PSEN2APH1B | |
| SCHEMBL6283051 | 0.83 | PSEN1 (0.49) | ATP4AATP4BPSEN1PSEN2APH1B | |
| SCHEMBL22780031 | 0.77 | GAA (0.71) | GAANPC1RAB9AGFERALDH1A1 | |
| SCHEMBL6642533 | 0.76 | ALDH1A1 (0.65) | GAANPC1RAB9AGFERALDH1A1 | |
| SCHEMBL6276725 | 0.76 | CYP1A2 (0.46) | NPC1RAB9AATP4AATP4BPSEN1 | |
| SCHEMBL28769725 | 0.76 | ATP4A (0.54) | ATP4AATP4BPSEN1PSEN2APH1B | |
| SCHEMBL6276279 | 0.74 | ALOX5 (0.56) | ATP4AATP4BPSEN1PSEN2APH1B | |
| SCHEMBL28772943 | 0.74 | ATP4A (0.50) | ATP4AATP4BPSEN1PSEN2APH1B | |
| SCHEMBL27701658 | 0.72 | ATP4A (0.48) | ATP4AATP4BPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849642-B2 | Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring | GRUENENTHAL GMBH (DE) | 2005-02-01 | — | — | US | claimed |
| EP-1218380-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | GRUENENTHAL GMBH (DE) | 2003-12-17 | — | — | EP | claimed |
| US-20020183327-A1 | Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring | GRUENENTHAL GMBH. | 2002-12-05 | — | — | US | claimed |
| US-6849642-B2 | Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring | GRUENENTHAL GMBH (DE) | 2005-02-01 | — | — | US | disclosed |
| US-20020183327-A1 | Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring | GRUENENTHAL GMBH. | 2002-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183327-A1 | Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring | OPRK1, GRIN3A, OPRM1 | GAA 3464/4885NPC1 956/4885RAB9A 2220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.