P-Xylene

P-Xylene

SCHEMBL6283872

Cc1ccc(C)cc1.O=C(O)CCc1nccs1

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 1/20 0.48
SLC6A3 Q01959 1/20 0.48
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 3/20 0.44
MAPT P10636 2/20 0.44
POLB P06746 1/20 0.44
FFAR1 O14842 5/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
KMT2A Q03164 2/20 0.42
DDAH1 O94760 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C19 P33261 1/20 0.41
MEN1 O00255 1/20 0.40
THRA P10827 1/20 0.40
THRB P10828 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL992041 0.90 FDPS (0.44) SLC6A3ALDH1A1KDM4EMAPTFFAR1
O-Xylene SCHEMBL6283877 0.88 PLA2G4A (0.43) SLC6A3ALDH1A1KDM4EMAPTPOLB
SCHEMBL6179956 0.80 SMN1; SMN2 (0.44) SLC6A3SMN1; SMN2ALDH1A1FFAR1
SCHEMBL11156307 0.78 PLA2G4A (0.48) MAPT
SCHEMBL4574427 0.78 ALDH1A1 (0.47) TRPM8SLC6A3SMN1; SMN2ALDH1A1KMT2A
SCHEMBL28011812 0.77 FDPS (0.46) TRPM8SLC6A3ALDH1A1MAPTKMT2A
SCHEMBL7174088 0.77 CES1 (0.49) MAPT
SCHEMBL5900543 0.75 ALDH1A1 (0.49) TRPM8RAB9ASMN1; SMN2ALDH1A1MAPT
SCHEMBL12530273 0.75 ALDH1A1 (0.44) TRPM8NPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL291399 0.75 ALDH1A1 (0.44) TRPM8NPC1RAB9ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005115148-A1 3-ARYL-3-HYDROXY-2-METHYLENEPROPIONIC ACID ESTERS AS FUNGICIDES CROPSOLUTION, INC. (US) 2005-12-08 WO disclosed