O-Xylene

O-Xylene

SCHEMBL6283877

Cc1ccccc1C.O=C(O)CCc1nccs1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G4A P47712 1/20 0.43
USP2 O75604 1/20 0.42
LMNA P02545 1/20 0.42
MAPK1 P28482 1/20 0.42
KDM4E B2RXH2 3/20 0.42
CTSA P10619 1/20 0.42
CES1 P23141 1/20 0.42
SLC6A3 Q01959 1/20 0.41
FFAR1 O14842 6/20 0.41
PKM P14618 2/20 0.41
KEAP1 Q14145 1/20 0.41
ALDH1A1 P00352 2/20 0.40
PLA2G7 Q13093 1/20 0.40
CYP1A2 P05177 1/20 0.40
POLB P06746 1/20 0.40
CYP3A4 P08684 1/20 0.40
MAPT P10636 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
FFAR4 Q5NUL3 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
P-Xylene SCHEMBL6283872 0.88 TRPM8 (0.48) KDM4ESLC6A3FFAR1ALDH1A1CYP1A2
SCHEMBL992041 0.87 FDPS (0.44) PLA2G4AKDM4ECES1SLC6A3FFAR1
SCHEMBL6179956 0.77 SMN1; SMN2 (0.44) PLA2G4AMAPK1CES1SLC6A3FFAR1
SCHEMBL11156307 0.76 PLA2G4A (0.48) PLA2G4ACES1MAPT
SCHEMBL4574427 0.75 ALDH1A1 (0.47) PLA2G4ACES1SLC6A3PKMALDH1A1
SCHEMBL28011812 0.75 FDPS (0.46) PLA2G4ACES1SLC6A3PKMALDH1A1
SCHEMBL7174088 0.74 CES1 (0.49) PLA2G4ACES1MAPT
SCHEMBL5900543 0.73 ALDH1A1 (0.49) LMNAPKMALDH1A1MAPT
SCHEMBL12530273 0.72 ALDH1A1 (0.44) PLA2G4ALMNAPKMALDH1A1CYP3A4
SCHEMBL291399 0.72 ALDH1A1 (0.44) LMNAPKMALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005115148-A1 3-ARYL-3-HYDROXY-2-METHYLENEPROPIONIC ACID ESTERS AS FUNGICIDES CROPSOLUTION, INC. (US) 2005-12-08 WO disclosed