Sugi Predict

Sugi Predict / Compounds / SCHEMBL6284947

SCHEMBL6284947

SCHEMBL6284947

CN1CC(c2ccc(-c3ccccc3)o2)OC1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B2 P37059 1/20 0.38
▸ SLC6A4 P31645 1/20 0.36
▸ BRD4 O60885 2/20 0.35
▸ GRM2 Q14416 1/20 0.35
▸ ALOX5 P09917 1/20 0.35
▸ CHRM2 P08172 1/20 0.35
▸ CHRM4 P08173 1/20 0.35
▸ CHRM5 P08912 1/20 0.35
▸ CHRM1 P11229 1/20 0.35
▸ CHRM3 P20309 1/20 0.35
▸ ALDH1A1 P00352 3/20 0.34
▸ MAPT P10636 3/20 0.34
▸ POLB P06746 2/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ LMNA P02545 1/20 0.34
▸ HPGD P15428 1/20 0.33
▸ FASN P49327 1/20 0.33
▸ FADS1 O60427 1/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ NPC1 O15118 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6363308 0.76 ALOX5 (0.33) GRM2ALOX5FADS1SMN1; SMN2
SCHEMBL7364885 0.75 FADS1 (0.50) BRD4ALOX5FADS1KDM4E
SCHEMBL7364886 0.75 FADS1 (0.50) BRD4ALOX5FADS1KDM4E
SCHEMBL5835616 0.75 FADS1 (0.50) BRD4ALOX5FADS1KDM4E
SCHEMBL6285030 0.71 ALDH1A1 (0.42) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL13394484 0.68 ALOX5 (0.38) BRD4GRM2ALOX5MAPK1
SCHEMBL15928322 0.67 HTR6 (0.52) GRM2ALOX5ALDH1A1KDM4EGAA
SCHEMBL6284106 0.67 ALOX5 (0.33) ALOX5
SCHEMBL12434744 0.65 BRD4 (0.42) BRD4GRM2ALOX5CHRM3ALDH1A1
SCHEMBL15743997 0.64 HTR2C (0.41) ALOX5MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6878705-B2 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide antiviral agents PFIZER (US) 2005-04-12 — — US disclosed
US-20050049245-A1 Heteroaryl-ethanolamine derivatives as antiviral agents PHARMACIA & UPJOHN COMPANY 2005-03-03 — — US disclosed
US-20040259907-A1 4-OXO-4,7-DIHYDROFURO[2,3-B]PYRIDINE-5-CARBOXAMIDE ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY 2004-12-23 — — US disclosed
WO-2004106345-A2 HETEROARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2004-12-09 — — WO disclosed
EP-1465895-A2 4-OXO-4,7-DIHYDROFURO(2,3-B)PYRIDINE-5-CARBOXAMIDE ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2004-10-13 — — EP disclosed
WO-2003059911-A2 4-OXO-4, 7-DIHYDROFURO[2,3-b]PYRIDINE-5-CARBOXAMIDE ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2003-07-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040259907-A1 4-OXO-4,7-DIHYDROFURO[2,3-B]PYRIDINE-5-CARBOXAMIDE ANTIVIRAL AGENTS IL4, ZC3HAV1, IRF3 HSD17B2 2628/4885SLC6A4 2199/4885BRD4 63/4885
US-20050049245-A1 Heteroaryl-ethanolamine derivatives as antiviral agents RPL35, ZC3HAV1, RPL5 HSD17B2 4323/4885SLC6A4 901/4885BRD4 172/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.