Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28289122 | 0.90 | ALDH1A1 (0.60) | NR4A2MAPTPOLBGPR84TP53 | |
| SCHEMBL6706855 | 0.85 | NR4A2 (0.56) | NR4A2GPR84TP53SMN1; SMN2NPSR1 | |
| SCHEMBL16044124 | 0.85 | NR4A2 (0.52) | NR4A2GPR84TP53SMN1; SMN2GABRA1 | |
| SCHEMBL2085712 | 0.84 | NR4A2 (0.69) | NR4A2GPR84SMN1; SMN2GABRA1GABRB1 | |
| SCHEMBL4907100 | 0.83 | KDM4E (0.54) | NR4A2GPR84TP53SMN1; SMN2NPSR1 | |
| SCHEMBL22955669 | 0.82 | F7 (0.71) | NR4A2GPR84GABRA1GABRB1GABRA3 | |
| SCHEMBL28289239 | 0.81 | ALDH1A1 (0.60) | MAPTPOLBTP53SMN1; SMN2GABRA1 | |
| SCHEMBL5434549 | 0.80 | NR4A2 (0.69) | NR4A2GPR84SMN1; SMN2GABRA1GABRB1 | |
| SCHEMBL3279652 | 0.80 | GPR84 (0.79) | NR4A2GPR84TP53SMN1; SMN2NPSR1 | |
| SCHEMBL29988308 | 0.80 | GPR84 (0.79) | NR4A2GPR84TP53SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6914145-B2 | Acylation process | PFIZER, INC. (US) | 2005-07-05 | — | — | US | disclosed |
| CN-1142140-C | Acylation method | ������ҩ������˾ | 2004-03-17 | — | — | CN | disclosed |
| EP-1088817-B1 | Process for the preparation of 3-acyl-indoles | PFIZER LTD (GB) | 2003-02-26 | — | — | EP | disclosed |
| US-20020188138-A1 | Acylation process | PFIZER INC. | 2002-12-12 | — | — | US | disclosed |
| US-6441192-B1 | ADDING ACID CHLORIDE AND ALKYL OR ARYL MAGNESIUM HALIDE SEPARATELY AND SIMULTANEOUSLY TO A STIRRED SOLUTION OF AN INDOLE SUCH THAT THE TWO REAGENTS DO NOT COME INTO IMMEDIATE CONTACT; SYNCHRONISED RATES OF MOLAR ADDITION | PFIZER INC. | 2002-08-27 | — | — | US | disclosed |
| CN-1290697-A | Acylation method | PFIZER (US) | 2001-04-11 | — | — | CN | disclosed |
| EP-1088817-A2 | Process for the preparation of 3-acyl-indoles | Pfizer Limited (GB) | 2001-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020188138-A1 | Acylation process | IDO1, IDO2, AANAT | NR4A2 3114/4885MAPT 2958/4885POLB 4669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.