SCHEMBL6285970

SCHEMBL6285970

N#CC(C#N)=C1CCc2cc(O)c(O)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 1.00
ADCY6 O43306 1/20 0.33
ADCY3 O60266 1/20 0.33
ADCY9 O60503 1/20 0.33
ADCY5 O95622 1/20 0.33
ADCY8 P40145 1/20 0.33
ADCY7 P51828 1/20 0.33
ADCY2 Q08462 1/20 0.33
ADCY1 Q08828 1/20 0.33
ADCY4 Q8NFM4 1/20 0.33
PTGS2 P35354 1/20 0.33
ACHE P22303 2/20 0.32
CDC42 P60953 2/20 0.32
RAC1 P63000 2/20 0.32
ALDH1A1 P00352 1/20 0.32
ADRB2 P07550 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19410119 0.77 EGFR (0.61) EGFRALDH1A1
SCHEMBL255282 0.71 EGFR (0.55) EGFRALDH1A1
SCHEMBL30067338 0.71 EGFR (0.55) EGFRALDH1A1
SCHEMBL2932814 0.69 PBRM1 (0.57) EGFRADCY6ADCY3ADCY9ADCY5
SCHEMBL29924694 0.65 ADCY6 (0.63) EGFRADCY6ADCY3ADCY9ADCY5
SCHEMBL30067531 0.65 HSD17B10 (0.51) EGFRALDH1A1
SCHEMBL254570 0.65 HSD17B10 (0.51) EGFRALDH1A1
SCHEMBL16977293 0.62 EGFR (0.45) EGFR
SCHEMBL423181 0.61 MAOA (0.60) EGFRADCY6ADCY3ADCY9ADCY5
SCHEMBL17988355 0.61 HTT (0.53) EGFRADCY6ADCY3ADCY9ADCY5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE38761-E1 Styryl compounds which inhibit EGF receptor protein tyrosine kinase YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2005-07-19 US disclosed
US-5217999-A Antigrowth agents YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1993-06-08 US disclosed
WO-1991016892-A1 STYRYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR PROTEIN TYROSINE KINASE RORER INTERNATIONAL (HOLDINGS), INC. (US) 1991-11-14 WO disclosed