Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.40 |
| ▸ | METAP1 | P53582 | 3/20 | 0.40 |
| ▸ | CBFB | Q13951 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.38 |
| ▸ | TCF4 | P15884 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951474 | 0.83 | CBFB (0.43) | CBFBKDM4ENPC1RAB9A | |
| SCHEMBL13373870 | 0.82 | NPC1 (0.51) | METAP2METAP1FGFR1FGFR2FGFR3 | |
| SCHEMBL5951763 | 0.80 | METAP1 (0.51) | METAP2METAP1CBFBAMY1AGUSB | |
| SCHEMBL1170649 | 0.75 | KDM4E (0.52) | METAP2METAP1CBFBTCF4CTNNB1 | |
| SCHEMBL5952179 | 0.75 | AMY1A (0.43) | METAP2METAP1CBFBAMY1AGUSB | |
| SCHEMBL19558136 | 0.75 | SMN1; SMN2 (0.51) | TCF4CTNNB1AMY1AKDM4ENPC1 | |
| SCHEMBL4812027 | 0.73 | METAP2 (0.55) | METAP2METAP1CBFBTCF4CTNNB1 | |
| SCHEMBL2867210 | 0.71 | AXL (0.53) | NPC1RAB9A | |
| SCHEMBL17255161 | 0.71 | NPC1 (0.47) | TCF4CTNNB1GUSBKDM4ENPC1 | |
| SCHEMBL9531057 | 0.71 | ALPL (0.40) | KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | disclosed |