⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9315437 | 0.74 | — | — | |
| SCHEMBL19584847 | 0.74 | — | — | |
| SCHEMBL6692736 | 0.74 | — | — | |
| SCHEMBL166454 | 0.74 | — | — | |
| SCHEMBL5250933 | 0.73 | — | — | |
| SCHEMBL7532666 | 0.72 | — | — | |
| SCHEMBL2430808 | 0.72 | ALDH1A1 (0.46) | — | |
| SCHEMBL6577704 | 0.72 | — | — | |
| SCHEMBL5143413 | 0.72 | LDHA (0.42) | — | |
| SCHEMBL28609539 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102627596-A | Preparation method of 4-hydroxy-2-oxo-1-pyrrolidine acetamide | TIANJIN JINGYIN PHARMACEUTICAL BIOTECHNOLOGY DEV CO LTD | 2012-08-08 | — | — | CN | claimed |
| EP-0967271-B1 | NOVEL CARBONYL REDUCTASE, GENE THAT ENCODES THE SAME, AND METHOD OF UTILIZING THESE | KANEKA CORP (JP) | 2004-10-20 | — | — | EP | claimed |
| EP-0912467-B1 | ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE | RHODIA CHIMIE SA (FR) | 2002-04-24 | — | — | EP | claimed |
| US-6218157-B1 | EFFICIENT METHOD BY REACTING A 4-HALOACETOACETIC ACID ESTER WITH PURIFIED ENZYME TO FORM (S)-4-HALO-3-HYDROXYBUTYRIC ACID ESTER | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2001-04-17 | — | — | US | claimed |
| US-20230400766-A1 | ONIUM SALT, RESIST COMPOSITION AND PATTERN FORMING PROCESS | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2023-12-14 | — | — | US | disclosed |
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | D. E. SHAW RESEARCH, LLC | 2020-10-01 | — | — | US | disclosed |
| EP-3681499-A1 | COMPOUNDS AS RAS INHIBITORS AND USE THEREOF | D.E. Shaw Research, LLC (US) | 2020-07-22 | — | — | EP | disclosed |
| WO-2019055540-A1 | COMPOUNDS AS RAS INHIBITORS AND USE THEREOF | D.E. SHAW RESEARCH, LLC (US) | 2019-03-21 | — | — | WO | disclosed |
| CN-104478719-A | 4-methoxy methyl acetoacetate preparation method | UNIV HENAN NORMAL | 2015-04-01 | — | — | CN | disclosed |
| CN-102627596-A | Preparation method of 4-hydroxy-2-oxo-1-pyrrolidine acetamide | TIANJIN JINGYIN PHARMACEUTICAL BIOTECHNOLOGY DEV CO LTD | 2012-08-08 | — | — | CN | disclosed |
| CN-102584649-A | Pyrro[1,2-b]pyridazinone compounds | ANADYS PHARMACEUTICALS INC | 2012-07-18 | — | — | CN | disclosed |
| US-20120077854-A1 | COMPOSITIONS AND METHODS FOR MODULATING RETINOL BINDING TO RETINOL BINDING PROTEIN 4 (RBP4) | IRM LLC (BM) | 2012-03-29 | — | — | US | disclosed |
| EP-0389178-A2 | Acrylamido-penicillanic-acid derivatives | BEECHAM GROUP PLC (GB) | 1990-09-26 | — | — | EP | disclosed |
| US-4954489-A | ACYLATION | BEECHAM GROUP P.L.C. (GB) | 1990-09-04 | — | — | US | disclosed |
| EP-0245315-B1 | PROCESS FOR PREPARING $g(a)-HYDROXY CARBONYL COMPOUNDS | L. GIVAUDAN & CIE Société Anonyme (CH) | 1990-04-11 | — | — | EP | disclosed |
| EP-0337643-A2 | 6-Substituted acrylamido penicillanic acid derivatives, preparation and use | BEECHAM GROUP PLC (GB) | 1989-10-18 | — | — | EP | disclosed |
| US-4710468-A | FROM OPTICALLY ACTIVE SUBSTITUTED HYDROXYBUTYRIC ACID DERIVATIVES WITH OXIDOREDUCTASE | SIGMA-TAU INDUSTRIE PHARMACEUTICHE RIUNITE S.P.A. (IT) | 1987-12-01 | — | — | US | disclosed |
| EP-0245315-A1 | PROCESS FOR PREPARING -g(a)-HYDROXY CARBONYL COMPOUNDS. | GIVAUDAN & CIE SA (CH) | 1987-11-19 | — | — | EP | disclosed |
| US-4472589-A | 4-Chloro-4-chloromethyloxetan-2-one | CIBA-GEIGY CORPORATION (US) | 1984-09-18 | — | — | US | disclosed |
| US-4398033-A | 4-Chloro-4-chloromethyloxetan-2-one and a process for its production | CIBA-GEIGY CORPORATION (US) | 1983-08-09 | — | — | US | disclosed |