Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288703 | 0.84 | ERN1 (0.55) | ERN1LCKMAPTALDH1A1KMT2A | |
| SCHEMBL18904700 | 0.80 | ERN1 (0.56) | ERN1LCKALDH1A1HTTTDP1 | |
| SCHEMBL11519347 | 0.78 | ERN1 (0.74) | ERN1LCKMAPTALDH1A1KMT2A | |
| SCHEMBL6288707 | 0.74 | MAPT (0.51) | LCKMAPTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL30067115 | 0.72 | ALDH1A1 (0.50) | ERN1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL19798736 | 0.71 | ERN1 (0.43) | ERN1LCKALDH1A1PTPN11NPC1 | |
| SCHEMBL14877029 | 0.71 | LCK (0.57) | ERN1LCKALDH1A1HTTALOX15 | |
| SCHEMBL2031300 | 0.70 | ALDH1A1 (0.56) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL532856 | 0.69 | ALDH1A1 (0.56) | MAPTALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL14521045 | 0.69 | ALDH1A1 (0.50) | ERN1MAPTALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849761-B2 | Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2005-02-01 | — | — | US | disclosed |
| US-20040127570-A1 | Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127570-A1 | Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia | INSR, GPR119, INSRR | ERN1 631/4885LCK 4362/4885MAPT 4803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.