Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18904700 | 0.87 | ERN1 (0.56) | ERN1LCKALDH1A1PTPN11CYP2C9 | |
| SCHEMBL30067115 | 0.87 | ALDH1A1 (0.50) | ERN1MAPTCYP3A4KMT2AALDH1A1 | |
| SCHEMBL6288683 | 0.84 | ERN1 (0.49) | ERN1LCKMAPTKMT2AALDH1A1 | |
| SCHEMBL11519347 | 0.84 | ERN1 (0.74) | ERN1LCKMAPTKMT2AALDH1A1 | |
| SCHEMBL4948601 | 0.79 | LCK (0.57) | LCKMAPTCYP3A4KMT2AALDH1A1 | |
| SCHEMBL18402724 | 0.79 | LCK (0.57) | LCKMAPTCYP3A4KMT2APTPN11 | |
| SCHEMBL8989547 | 0.79 | ERN1 (0.46) | ERN1MAPTALDH1A1CYP2C9ATM | |
| SCHEMBL30067092 | 0.79 | ERN1 (0.46) | ERN1MAPTALDH1A1CYP2C9ATM | |
| SCHEMBL19798736 | 0.77 | ERN1 (0.43) | ERN1LCKALDH1A1PTPN11 | |
| SCHEMBL14047249 | 0.77 | ACHE (0.46) | ERN1MAPTCYP3A4KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849761-B2 | Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2005-02-01 | — | — | US | disclosed |
| US-20040127570-A1 | Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127570-A1 | Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia | INSR, GPR119, INSRR | ERN1 631/4885LCK 4362/4885MAPT 4803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.