Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | EDNRB | P24530 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21480088 | 0.85 | NPC1 (0.48) | CES2CES1LMNAEDNRBEDNRA | |
| SCHEMBL1356271 | 0.84 | AKR1C3 (0.52) | CES2CES1LMNAEDNRBEDNRA | |
| SCHEMBL1368545 | 0.83 | CES2 (0.49) | CES2CES1LMNAEDNRBEDNRA | |
| SCHEMBL4693833 | 0.83 | CES2 (0.49) | CES2CES1LMNAEDNRBEDNRA | |
| SCHEMBL15430216 | 0.81 | PKM (0.58) | CES2CES1LMNAEDNRBEDNRA | |
| SCHEMBL2797715 | 0.81 | CES2 (0.50) | CES2CES1LMNAEDNRBEDNRA | |
| SCHEMBL4958167 | 0.81 | CES2 (0.50) | CES2CES1LMNAEDNRBEDNRA | |
| SCHEMBL31256902 | 0.79 | CES2 (0.49) | CES2CES1LMNAEDNRBEDNRA | |
| SCHEMBL22285693 | 0.79 | CES2 (0.49) | CES2CES1LMNAEDNRBEDNRA | |
| SCHEMBL9654996 | 0.79 | PARP1 (0.50) | CES2CES1LMNAEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150218144-A1 | SUBSTITUTED PHENYLCARBAMATE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-08-06 | — | — | US | disclosed |
| US-6838584-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2005-01-04 | — | — | US | disclosed |
| US-20040162304-A1 | Estrogen receptor modulators | MERCK & CO., INC. | 2004-08-19 | — | — | US | disclosed |
| EP-1387821-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-02-11 | — | — | EP | disclosed |
| WO-2002091993-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218144-A1 | SUBSTITUTED PHENYLCARBAMATE COMPOUNDS | TRPA1, TRPV1, TRPV3 | CES2 852/4885CES1 887/4885LMNA 3240/4885 |
| US-20040162304-A1 | Estrogen receptor modulators | ESRRA, GPER1, ESRRB | CES2 2801/4885CES1 330/4885LMNA 1353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.