SCHEMBL629078

SCHEMBL629078

C=CCn1nccc(Cl)c1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 1/20 0.41
CASP3 P42574 2/20 0.37
ALDH1A1 P00352 7/20 0.36
SMN1; SMN2 Q16637 4/20 0.36
HTT P42858 3/20 0.36
LMNA P02545 2/20 0.36
MITF O75030 2/20 0.36
POLB P06746 2/20 0.36
RECQL P46063 1/20 0.36
MCL1 Q07820 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
GAA P10253 3/20 0.35
MAPT P10636 1/20 0.35
RAB9A P51151 4/20 0.35
KDM4E B2RXH2 3/20 0.33
HPGD P15428 2/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9674402 0.76 HTT (0.55) CYP3A4CYP1A2CYP2D6ALDH1A1SMN1; SMN2
SCHEMBL1414572 0.75
SCHEMBL27984511 0.75 KMT2A (0.45) ALDH1A1SMN1; SMN2HTTMITFPOLB
SCHEMBL31104020 0.73 HTT (0.31) ALDH1A1SMN1; SMN2HTTMITFPOLB
SCHEMBL9727068 0.73 HTT (0.41) CYP3A4CYP1A2CYP2D6CASP3ALDH1A1
SCHEMBL25342529 0.72 NLRP3 (0.47) ALDH1A1SMN1; SMN2HTTLMNAMITF
SCHEMBL7376931 0.72 CASP3 (0.38) CYP3A4CYP1A2CYP2D6CASP3ALDH1A1
SCHEMBL2720779 0.72 RAB9A (0.33) CYP3A4CASP3ALDH1A1SMN1; SMN2HTT
SCHEMBL27266543 0.71 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2HTTLMNAMITF
SCHEMBL1367696 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180071411-A1 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID LANTHEUS MEDICAL IMAGING, INC. (US) 2018-03-15 US claimed
US-20130101508-A9 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID LANTHEUS MEDICAL IMAGING, INC. (US) 2013-04-25 US claimed
US-20120237445-A1 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID LANTHEUS MEDICAL IMAGING, INC. (US) 2012-09-20 US claimed
CN-102458396-A Stabilization of radiopharmaceutical compositions using ascorbic acid LANTHEUS MEDICAL IMAGING INC 2012-05-16 CN claimed
EP-2419096-A2 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID Lantheus Medical Imaging, Inc. (US) 2012-02-22 EP claimed
WO-2010120368-A2 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID LANTHEUS MEDICAL IMAGING, INC. (US) 2010-10-21 WO claimed
CN-107261159-B Stabilization of radiopharmaceutical compositions using ascorbic acid 兰休斯医疗成像公司 2021-01-12 CN disclosed
US-20200222562-A1 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID LANTHEUS MEDICAL IMAGING, INC. (US) 2020-07-16 US disclosed
EP-2419096-B1 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID LANTHEUS MEDICAL IMAGING INC (US) 2019-11-13 EP disclosed
US-20180071411-A1 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID LANTHEUS MEDICAL IMAGING, INC. (US) 2018-03-15 US disclosed
US-9687571-B2 Stabilization of radiopharmaceutical compositions using ascorbic acid LANTHEUS MEDICAL IMAGING, INC. (US) 2017-06-27 US disclosed
US-20130101508-A9 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID LANTHEUS MEDICAL IMAGING, INC. (US) 2013-04-25 US disclosed
US-20120237445-A1 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID LANTHEUS MEDICAL IMAGING, INC. (US) 2012-09-20 US disclosed
CN-102458396-A Stabilization of radiopharmaceutical compositions using ascorbic acid LANTHEUS MEDICAL IMAGING INC 2012-05-16 CN disclosed
EP-2419096-A2 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID Lantheus Medical Imaging, Inc. (US) 2012-02-22 EP disclosed
WO-2010120368-A2 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID LANTHEUS MEDICAL IMAGING, INC. (US) 2010-10-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200222562-A1 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID TTPA, PROC, RBP1 CYP3A4 1977/4885CYP1A2 1304/4885CYP2D6 447/4885
US-20180071411-A1 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID TTPA, PROC, RBP1 CYP3A4 1977/4885CYP1A2 1304/4885CYP2D6 447/4885
US-20120237445-A1 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID TTPA, PROC, RBP1 CYP3A4 1977/4885CYP1A2 1304/4885CYP2D6 447/4885
US-20130101508-A9 STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS USING ASCORBIC ACID TTPA, PROC, RBP1 CYP3A4 1977/4885CYP1A2 1304/4885CYP2D6 447/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.