Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6292862 | 0.86 | TMEM97 (0.58) | P2RX7TMEM97SIGMAR1TAS1R3TAS1R1 | |
| SCHEMBL2569892 | 0.85 | TMEM97 (0.56) | P2RX7TMEM97SIGMAR1TAS1R3TAS1R1 | |
| SCHEMBL5529489 | 0.85 | HPGD (0.62) | P2RX7TMEM97SIGMAR1TAS1R3TAS1R1 | |
| SCHEMBL9491955 | 0.82 | TAS1R3 (0.57) | P2RX7TMEM97SIGMAR1TAS1R3TAS1R1 | |
| SCHEMBL6947954 | 0.82 | TMEM97 (0.53) | P2RX7TMEM97SIGMAR1TAS1R3TAS1R1 | |
| SCHEMBL4158170 | 0.81 | TAS1R3 (0.64) | P2RX7TMEM97SIGMAR1TAS1R3TAS1R1 | |
| SCHEMBL11570780 | 0.81 | TAS1R3 (0.55) | P2RX7TMEM97SIGMAR1TAS1R3TAS1R1 | |
| SCHEMBL8743573 | 0.79 | GPR139 (0.60) | P2RX7TMEM97SIGMAR1TAS1R3TAS1R1 | |
| SCHEMBL28358650 | 0.79 | LMNA (0.53) | P2RX7TMEM97SIGMAR1NPC1HPGD | |
| SCHEMBL4384455 | 0.78 | TAS1R3 (0.60) | P2RX7TMEM97SIGMAR1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867200-B1 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | disclosed |