Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | STAT6 | P42226 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11132712 | 0.87 | IMPDH2 (0.44) | IMPDH2IMPDH1IDO1EP300KAT8 | |
| SCHEMBL2687596 | 0.78 | CA1 (0.46) | KMT2AALDH1A1HTTCA12CA1 | |
| SCHEMBL28211173 | 0.75 | CYP1A1 (0.37) | MAPTHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL31601025 | 0.75 | — | — | |
| SCHEMBL29380721 | 0.74 | IDO1 (0.73) | IMPDH2IMPDH1IDO1EP300KAT8 | |
| SCHEMBL419307 | 0.74 | IDO1 (0.73) | IMPDH2IMPDH1IDO1EP300KAT8 | |
| SCHEMBL9671799 | 0.74 | ALDH1A1 (0.33) | MAPTKMT2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8777998 | 0.72 | CHEK1 (0.46) | EP300KAT8MAPTKMT2AALDH1A1 | |
| SCHEMBL11409076 | 0.70 | CA12 (0.48) | IDO1MAPTHPGDKMT2ACYP2C9 | |
| SCHEMBL10564377 | 0.70 | CA12 (0.48) | MAPTHPGDKMT2ACYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6955921-B2 | Trypsin substrate and diagnostic device, and method of using same | BAYER CORPORATION (US) | 2005-10-18 | — | — | US | disclosed |
| US-6770764-B2 | DIAGNOSIS OF BACTERIA INFECTIONS | BAYER CORPORATION | 2004-08-03 | — | — | US | disclosed |
| US-20030125577-A1 | Trypsin substrate and diagnostic device, and method of using same | SIEMENS HEALTHCARE DIAGNOSTICS INC. | 2003-07-03 | — | — | US | disclosed |
| US-20020004219-A1 | Trypsin substrate and diganostic device, and method of using same | SIEMENS HEALTHCARE DIAGNOSTICS INC. | 2002-01-10 | — | — | US | disclosed |
| EP-1157984-A2 | Trypsin substrate and diagnostic device, and method of using same | Bayer Corporation (US) | 2001-11-28 | — | — | EP | disclosed |
| US-4749648-A | Agent for the determination of esterolytic and/or proteolytic enzymes | BOEHRINGER MANNHEIM GMBH (DE) | 1988-06-07 | — | — | US | disclosed |
| US-4551428-A | COLORIMETRIC ANALYSIS USING DIAZONIUM COUPLERS | BOEHRINGER MANNHEIM GMBH (DE) | 1985-11-05 | — | — | US | disclosed |
| EP-0039880-B1 | AGENTS FOR THE DETECTION OF ESTEROLYTIC AND/OR PROTEOLYTIC ENZYMES; AND PHENOXY-AMINO ACIDS AND PHENOXY-PEPTIDE ESTERS SUITABLE AS SUBSTRATES THEREFOR, PROCESS FOR THEIR PRODUCTION AND THEIR USE IN PRODUCING THE AGENTS | Roche Diagnostics GmbH (DE) | 1983-06-29 | — | — | EP | disclosed |
| EP-0039880-A1 | Agents for the detection of esterolytic and/or proteolytic enzymes; and phenoxy-amino acids and phenoxy-peptide esters suitable as substrates therefor, process for their production and their use in producing the agents | Roche Diagnostics GmbH (DE) | 1981-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020004219-A1 | Trypsin substrate and diganostic device, and method of using same | PRSS3, CTRL, PRSS2 | IMPDH2 1644/4885IMPDH1 828/4885IDO1 481/4885 |
| US-20030125577-A1 | Trypsin substrate and diagnostic device, and method of using same | CTRL, PRSS3, SPINT2 | IMPDH2 2229/4885IMPDH1 1262/4885IDO1 485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.