Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | BACE1 | P56817 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 2/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18528795 | 0.86 | NPC1 (0.69) | KDM4EALDH1A1CYP1A2POLBCYP2C19 | |
| SCHEMBL31595791 | 0.84 | NPC1 (0.51) | KDM4EALDH1A1CYP1A2POLBCYP2C19 | |
| SCHEMBL23451665 | 0.81 | KDM4E (0.64) | KDM4EALDH1A1CYP1A2POLBCYP2C19 | |
| SCHEMBL2093814 | 0.80 | BCHE (0.55) | KDM4EALDH1A1CYP1A2POLBCYP2C19 | |
| SCHEMBL21776988 | 0.80 | RAB9A (0.57) | KDM4EALDH1A1CYP1A2POLBCYP2C19 | |
| SCHEMBL22116712 | 0.79 | NPC1 (0.57) | KDM4EALDH1A1CYP1A2POLBCYP2C19 | |
| SCHEMBL5754354 | 0.79 | KDM4E (0.71) | KDM4EALDH1A1CYP1A2POLBCYP2C19 | |
| SCHEMBL29121393 | 0.79 | NPC1 (0.71) | KDM4EALDH1A1CYP1A2POLBCYP2C19 | |
| SCHEMBL23451582 | 0.79 | NPC1 (0.72) | KDM4EPOLBHSD17B10NPC1ACHE | |
| SCHEMBL31512896 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1CYP1A2POLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| EP-3843844-A1 | COMPOUNDS | UCL Business Ltd (GB) | 2021-07-07 | — | — | EP | disclosed |
| US-20210171475-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2021-06-10 | — | — | US | disclosed |
| WO-2020043866-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | KDM4E 3907/4885ALDH1A1 1260/4885CYP1A2 2434/4885 |
| US-20210171475-A1 | COMPOUNDS | GOT2, GOT1, OAT | KDM4E 4149/4885ALDH1A1 658/4885CYP1A2 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.