Sugi Predict

Sugi Predict / Compounds / SCHEMBL630047

SCHEMBL630047

SCHEMBL630047

COC(=O)c1ccc(N)cc1-c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 3/20 0.58
▸ ALDH1A1 P00352 5/20 0.54
▸ HPGD P15428 3/20 0.54
▸ MAPT P10636 3/20 0.54
▸ MEN1 O00255 2/20 0.54
▸ KMT2A Q03164 2/20 0.54
▸ SLC6A3 Q01959 5/20 0.50
▸ SLC6A4 P31645 3/20 0.50
▸ HSD17B10 Q99714 2/20 0.50
▸ LMNA P02545 2/20 0.50
▸ PTGDR2 Q9Y5Y4 1/20 0.50
▸ PRKCZ Q05513 1/20 0.50
▸ GABRA1 P14867 1/20 0.50
▸ GABRG2 P18507 1/20 0.50
▸ GABRB3 P28472 1/20 0.50
▸ GABRA3 P34903 1/20 0.50
▸ CFTR P13569 1/20 0.50
▸ SLC6A2 P23975 2/20 0.48
▸ EGFR P00533 1/20 0.47
▸ KDM4E B2RXH2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29775249 1.00 GAA (0.58) GAAALDH1A1HPGDMAPTMEN1
Hydrochloric Acid SCHEMBL6625663 0.98 GAA (0.57) GAAALDH1A1HPGDMAPTMEN1
SCHEMBL2726928 0.87 GAA (0.54) GAAALDH1A1HPGDMAPTMEN1
SCHEMBL7662993 0.84 SLC6A3 (0.63) GAAALDH1A1HPGDMAPTSLC6A3
SCHEMBL2723555 0.84 SLC6A3 (0.63) GAAALDH1A1HPGDMAPTSLC6A3
SCHEMBL5099626 0.84 ABL1 (0.54) GAAALDH1A1HPGDMAPTMEN1
SCHEMBL12121707 0.83 GABRA1 (0.62) GAAALDH1A1HPGDMAPTMEN1
SCHEMBL818748 0.82 PTGS2 (0.59) GAAALDH1A1HPGDMAPTMEN1
SCHEMBL4472418 0.82 CA12 (0.59) GAAALDH1A1HPGDMAPTMEN1
SCHEMBL6776148 0.82 HDAC7 (0.67) GAAALDH1A1HPGDMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12637433-B2 Histone deacetylase inhibitors THE UNIVERSITY OF QUEENSLAND (AU) 2026-05-26 — — US disclosed
US-20240109847-A1 HISTONE DEACETYLASE INHIBITORS THE UNIVERSITY OF QUEENSLAND (AU) 2024-04-04 — — US disclosed
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-02-23 — — US disclosed
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-02-23 — — US disclosed
WO-2022133551-A1 HISTONE DEACETYLASE INHIBITORS THE UNIVERSITY OF QUEENSLAND (AU) 2022-06-30 — — WO disclosed
WO-2021239117-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI) , INC. (CN) 2021-12-02 — — WO disclosed
EP-0986384-B1 INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES UNIV PITTSBURGH (US) 2012-02-22 — — EP disclosed
EP-0986384-A1 INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES UNIVERSITY OF PITTSBURGH (US) 2000-03-22 — — EP disclosed
WO-1999020612-A1 IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS ASTRAZENECA UK LIMITED (GB) 1999-04-29 — — WO disclosed
EP-0873123-A4 INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES UNIV PITTSBURGH (US) 1999-02-03 — — EP disclosed
WO-1998050030-A1 INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES UNIVERSITY OF PITTSBURGH (US) 1998-11-12 — — WO disclosed
WO-1998050029-A1 INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES UNIVERSITY OF PITTSBURGH (US) 1998-11-12 — — WO disclosed
WO-1998050031-A1 INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES UNIVERSITY OF PITTSBURGH (US) 1998-11-12 — — WO disclosed
EP-0873123-A1 INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES UNIVERSITY OF PITTSBURGH (US) 1998-10-28 — — EP disclosed
WO-1997017070-A1 INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES UNIVERSITY OF PITTSBURGH (US) 1997-05-15 — — WO disclosed
US-4201707-A Methine dyestuffs containing a phenyl azo group BAYER AKTIENGESELLSCHAFT (DE) 1980-05-06 — — US disclosed
US-4138570-A METHINE DYE BAYER AKTIENGESELLSCHAFT (DE) 1979-02-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12637433-B2 Histone deacetylase inhibitors HDAC1, HDAC11, HDAC3 GAA 1205/4885ALDH1A1 1976/4885HPGD 1474/4885
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 GAA 2196/4885ALDH1A1 1427/4885HPGD 3064/4885
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 GAA 2196/4885ALDH1A1 1427/4885HPGD 3064/4885
US-20240109847-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC3, HDAC11 GAA 79/4885ALDH1A1 245/4885HPGD 275/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.