Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.50 |
| ▸ | CFTR | P13569 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630047 | 0.87 | GAA (0.58) | GAAKDM4EALDH1A1MEN1HPGD | |
| SCHEMBL29775249 | 0.87 | GAA (0.58) | GAAKDM4EALDH1A1MEN1HPGD | |
| SCHEMBL9705197 | 0.86 | GAA (0.65) | GAAKDM4ECYP1A2CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL6625663 | 0.86 | GAA (0.57) | GAAKDM4EALDH1A1MEN1HPGD | |
| SCHEMBL1982854 | 0.84 | SLC6A3 (0.61) | GAAKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL27386788 | 0.83 | EGFR (0.65) | GAAKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL12121707 | 0.83 | GABRA1 (0.62) | GAAKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1775361 | 0.82 | CYP46A1 (0.72) | GAAKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL5312865 | 0.82 | KDM4E (0.59) | GAAKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL10058712 | 0.82 | EGFR (0.63) | GAAKDM4ECYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399322-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2023-12-14 | — | — | US | disclosed |
| US-20230399322-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2023-12-14 | — | — | US | disclosed |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| US-9493438-B2 | 4,4-difluoro-piperidine-compounds | ROTTAPHARM S.R.L. (IT) | 2016-11-15 | — | — | US | disclosed |
| US-9493438-B2 | 4,4-difluoro-piperidine-compounds | ROTTAPHARM S.R.L. (IT) | 2016-11-15 | — | — | US | disclosed |
| US-9493438-B2 | 4,4-difluoro-piperidine-compounds | ROTTAPHARM S.R.L. (IT) | 2016-11-15 | — | — | US | disclosed |
| EP-2820007-B1 | 4,4-DIFLUORO-PIPERIDINE-COMPOUNDS | Rottapharm Biotech Srl (IT) | 2016-04-20 | — | — | EP | disclosed |
| EP-2820007-B1 | 4,4-DIFLUORO-PIPERIDINE-COMPOUNDS | Rottapharm Biotech Srl (IT) | 2016-04-20 | — | — | EP | disclosed |
| US-20150051226-A1 | 4,4-DIFLUORO-PIPERIDINE-COMPOUNDS | ROTTAPHARM S.P.A. (IT) | 2015-02-19 | — | — | US | disclosed |
| US-20150051226-A1 | 4,4-DIFLUORO-PIPERIDINE-COMPOUNDS | ROTTAPHARM S.P.A. (IT) | 2015-02-19 | — | — | US | disclosed |
| US-20150051226-A1 | 4,4-DIFLUORO-PIPERIDINE-COMPOUNDS | ROTTAPHARM S.P.A. (IT) | 2015-02-19 | — | — | US | disclosed |
| EP-2820007-A1 | 4,4-DIFLUORO-PIPERIDINE-COMPOUNDS | Rottapharm Biotech S.r.l. (IT) | 2015-01-07 | — | — | EP | disclosed |
| EP-2635279-A2 | CHEMICAL COMPOUNDS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-11 | — | — | EP | disclosed |
| WO-2013127913-A1 | 4,4-DIFLUORO-PIPERIDINE-COMPOUNDS | ROTTAPHARM S.P.A. (IT) | 2013-09-06 | — | — | WO | disclosed |
| WO-2013127913-A1 | 4,4-DIFLUORO-PIPERIDINE-COMPOUNDS | ROTTAPHARM S.P.A. (IT) | 2013-09-06 | — | — | WO | disclosed |
| US-20130225524-A1 | Chemical Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2013-08-29 | — | — | US | disclosed |
| WO-2012061557-A2 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230399322-A1 | EIF4E INHIBITORS AND USES THEREOF | EIF4E, EIF4EBP1, EIF4A1 | GAA 2552/4885KDM4E 710/4885CYP1A2 4834/4885 |
| US-20130225524-A1 | Chemical Compounds | LDHA, NQO2, LDHB | GAA 387/4885KDM4E 1541/4885CYP1A2 128/4885 |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | EIF4E, EIF4EBP1, EIF4A1 | GAA 2552/4885KDM4E 710/4885CYP1A2 4834/4885 |
| US-20150051226-A1 | 4,4-DIFLUORO-PIPERIDINE-COMPOUNDS | SLCO4C1, PAICS, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | GAA 2482/4885KDM4E 1234/4885CYP1A2 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.