Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628369 | 0.81 | KIF11 (0.58) | CHEK1MAPTAURKAPARP1MEN1 | |
| SCHEMBL2628367 | 0.81 | ACHE (0.56) | CHEK1MAPTAURKAPARP1MEN1 | |
| SCHEMBL12395872 | 0.79 | CHEK1 (0.63) | CHEK1MAPTAURKAPARP1MEN1 | |
| SCHEMBL30322758 | 0.76 | AURKA (0.65) | CHEK1MAPTAURKAPARP1KMT2A | |
| SCHEMBL12396544 | 0.76 | AURKA (0.65) | CHEK1MAPTAURKAPARP1KMT2A | |
| SCHEMBL29559082 | 0.75 | PARP1 (0.60) | CHEK1MAPTAURKAPARP1MEN1 | |
| SCHEMBL29410201 | 0.75 | PARP1 (0.60) | CHEK1MAPTAURKAPARP1MEN1 | |
| SCHEMBL9145 | 0.75 | PARP1 (0.60) | CHEK1MAPTAURKAPARP1MEN1 | |
| SCHEMBL4958620 | 0.75 | CHEK1 (0.50) | CHEK1MAPTAURKAPARP1MEN1 | |
| SCHEMBL22433744 | 0.74 | ERBB2 (0.50) | CHEK1MAPTAURKAPARP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858622-B2 | Cycloalkano-indole and -azaindole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2005-02-22 | — | — | US | disclosed |
| CN-1183111-C | Cycloalkano-indote and againdole derivatives, process for their preparation and pharmaceutical composition containing the same | — | 2005-01-05 | — | — | CN | disclosed |
| EP-0705831-B1 | Cycloalkano-indole- and -azaindole derivatives | BAYER AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| US-20030149073-A1 | Cycloalkano-indole and -azaindole derivatives | MULLER ULRICH (DE) | 2003-08-07 | — | — | US | disclosed |
| US-6479503-B2 | SUCH AS 2-(S/R)-2-(4-(2,4-DIMETHYL-5,6,7,8-TETRAHYDRO-ALPHA-CARBOLIN-9-YL)METHYL -PHENYL)-2-CYCLOPENTYL-ACETIC ACID N-((R)PHENYLGLYCINOAMIDE) FOR TREATING ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-11-12 | — | — | US | disclosed |
| US-20020147209-A1 | Cycloalkano-indole and -azaindole derivatives | MUELLER ULRICH (DE) | 2002-10-10 | — | — | US | disclosed |
| US-20020055635-A1 | Cycloalkano-indole and -azaindole derivatives | MULLER ULRICH (DE) | 2002-05-09 | — | — | US | disclosed |
| US-6265431-B1 | ANTICHOLESTEROL DRUGS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-07-24 | — | — | US | disclosed |
| US-6245775-B1 | ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-06-12 | — | — | US | disclosed |
| CN-1224715-A | Cycloalkano-indote and againdole derivatives, process for their preparation and pharmaceutical composition containing the same | BAYER AG (DE) | 1999-08-04 | — | — | CN | disclosed |
| US-5684014-A | FOR TREATING ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-11-04 | — | — | US | disclosed |
| CN-1130631-A | Cycloalkano-indole and-azaindole derivatives | BAYER AG (DE) | 1996-09-11 | — | — | CN | disclosed |
| EP-0705831-A2 | Cycloalkano-indole- and -azaindole derivatives | BAYER AG (DE) | 1996-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149073-A1 | Cycloalkano-indole and -azaindole derivatives | AADAC, IDO1, AADAT | CHEK1 2203/4885MAPT 3135/4885AURKA 372/4885 |
| US-20020147209-A1 | Cycloalkano-indole and -azaindole derivatives | AADAC, IDO1, AADAT | CHEK1 2203/4885MAPT 3135/4885AURKA 372/4885 |
| US-20020055635-A1 | Cycloalkano-indole and -azaindole derivatives | ADRB3, AADAT, INMT | CHEK1 2935/4885MAPT 3405/4885AURKA 821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.