Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LIG1 | P18858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL27332773 | 0.93 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRMAPTL3MBTL1 | |
| SCHEMBL2150775 | 0.84 | ALDH1A1 (0.55) | ALDH1A1KDM4ETSHRMAPTL3MBTL1 | |
| SCHEMBL3766260 | 0.84 | MAPT (0.49) | ALDH1A1KDM4ETSHRMAPTL3MBTL1 | |
| SCHEMBL14151108 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KDM4ETSHRMAPTL3MBTL1 | |
| SCHEMBL5085750 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KDM4ETSHRMAPTL3MBTL1 | |
| SCHEMBL23680099 | 0.81 | KDM4E (0.55) | ALDH1A1KDM4ETSHRMAPTL3MBTL1 | |
| 1,2-Diallyloxybenzene SCHEMBL366516 | 0.81 | HPGD (0.60) | ALDH1A1KDM4ETSHRMAPTL3MBTL1 | |
| 1,2-Diallyloxybenzene SCHEMBL29768784 | 0.81 | HPGD (0.60) | ALDH1A1KDM4ETSHRMAPTL3MBTL1 | |
| SCHEMBL7334313 | 0.81 | ALDH1A1 (0.53) | ALDH1A1KDM4ETSHRMAPTL3MBTL1 | |
| SCHEMBL9259701 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4ETSHRMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4597903-A | Process for the direct preparation of N,N-disubstituted derivatives for 4,13-diaza-18-crown-6 | UNIVERSITY OF MARYLAND (US) | 1986-07-01 | — | — | US | claimed |
| EP-3854789-A1 | MACROCYCLIC COMPOUNDS USEFUL AS CHITINASE INHIBITORS | CYGNET BIOSCIENCES B.V. (CW) | 2021-07-28 | — | — | EP | disclosed |
| US-10071975-B2 | Macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors | CYGNET BIOSCIENCES B.V. (CW) | 2018-09-11 | — | — | US | disclosed |
| EP-3010896-B1 | NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS | CYGNET BIOSCIENCES B V (CW) | 2017-11-01 | — | — | EP | disclosed |
| EP-3010896-B1 | NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS | CYGNET BIOSCIENCES B V (CW) | 2017-11-01 | — | — | EP | disclosed |
| EP-3114129-A1 | IMIDAZOPYRIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV Healthcare UK (No.5) Limited (GB) | 2017-01-11 | — | — | EP | disclosed |
| US-9409922-B2 | Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-08-09 | — | — | US | disclosed |
| US-20160137617-A1 | NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS | CYGNET BIOSCIENCES B.V. | 2016-05-19 | — | — | US | disclosed |
| US-20160137617-A1 | NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS | CYGNET BIOSCIENCES B.V. | 2016-05-19 | — | — | US | disclosed |
| US-20160137617-A1 | NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS | CYGNET BIOSCIENCES B.V. | 2016-05-19 | — | — | US | disclosed |
| EP-0705831-B1 | Cycloalkano-indole- and -azaindole derivatives | BAYER AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| US-20030149073-A1 | Cycloalkano-indole and -azaindole derivatives | MULLER ULRICH (DE) | 2003-08-07 | — | — | US | disclosed |
| US-6479503-B2 | SUCH AS 2-(S/R)-2-(4-(2,4-DIMETHYL-5,6,7,8-TETRAHYDRO-ALPHA-CARBOLIN-9-YL)METHYL -PHENYL)-2-CYCLOPENTYL-ACETIC ACID N-((R)PHENYLGLYCINOAMIDE) FOR TREATING ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-11-12 | — | — | US | disclosed |
| US-20020147209-A1 | Cycloalkano-indole and -azaindole derivatives | MUELLER ULRICH (DE) | 2002-10-10 | — | — | US | disclosed |
| US-20020055635-A1 | Cycloalkano-indole and -azaindole derivatives | MULLER ULRICH (DE) | 2002-05-09 | — | — | US | disclosed |
| US-6265431-B1 | ANTICHOLESTEROL DRUGS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-07-24 | — | — | US | disclosed |
| US-6245775-B1 | ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-06-12 | — | — | US | disclosed |
| US-5684014-A | FOR TREATING ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-11-04 | — | — | US | disclosed |
| CN-1130631-A | Cycloalkano-indole and-azaindole derivatives | BAYER AG (DE) | 1996-09-11 | — | — | CN | disclosed |
| EP-0705831-A2 | Cycloalkano-indole- and -azaindole derivatives | BAYER AG (DE) | 1996-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137617-A1 | NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS | CHIT1, CHIA, ENGASE | ALDH1A1 4141/4885KDM4E 3681/4885TSHR 1973/4885 |
| US-20030149073-A1 | Cycloalkano-indole and -azaindole derivatives | AADAC, IDO1, AADAT | ALDH1A1 1034/4885KDM4E 2676/4885TSHR 3042/4885 |
| US-10071975-B2 | Macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors | CHIT1, CHIA, PEPD | ALDH1A1 3977/4885KDM4E 3542/4885TSHR 2280/4885 |
| US-20020147209-A1 | Cycloalkano-indole and -azaindole derivatives | AADAC, IDO1, AADAT | ALDH1A1 1034/4885KDM4E 2676/4885TSHR 3042/4885 |
| US-20020055635-A1 | Cycloalkano-indole and -azaindole derivatives | ADRB3, AADAT, INMT | ALDH1A1 1445/4885KDM4E 3593/4885TSHR 2697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.