Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ1 | P51787 | 2/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 11/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630219 | 0.89 | KCNQ1 (0.58) | KCNQ1HCRTR1HCRTR2BDKRB1POLB | |
| SCHEMBL631050 | 0.87 | KCNQ1 (0.47) | KCNQ1HCRTR1HCRTR2BDKRB1GAA | |
| SCHEMBL630680 | 0.86 | KCNQ1 (0.48) | KCNQ1HCRTR1HCRTR2BDKRB1GAA | |
| SCHEMBL629908 | 0.85 | KCNQ1 (0.46) | KCNQ1HCRTR1HCRTR2BDKRB1GAA | |
| SCHEMBL631034 | 0.84 | KCNQ1 (0.44) | KCNQ1HCRTR1HCRTR2BDKRB1POLB | |
| SCHEMBL630055 | 0.84 | KCNQ1 (0.47) | KCNQ1HCRTR1HCRTR2BDKRB1GAA | |
| SCHEMBL631253 | 0.81 | BDKRB1 (0.42) | KCNQ1BDKRB1POLB | |
| SCHEMBL631454 | 0.80 | BDKRB1 (0.45) | KCNQ1BDKRB1GAALMNANPSR1 | |
| SCHEMBL630671 | 0.80 | POLB (0.46) | KCNQ1HCRTR1HCRTR2BDKRB1GAA | |
| SCHEMBL629860 | 0.80 | BDKRB1 (0.41) | KCNQ1BDKRB1MAPTPOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-B1 | FKBP-binding composition and pharmaceutical use thereof | AVENTIS PHARMA INC (US) | 2012-02-22 | — | — | EP | claimed |