Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ1 | P51787 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630614 | 0.92 | POLB (0.44) | KCNQ1HCRTR1HCRTR2POLBKMT2A | |
| SCHEMBL629759 | 0.90 | KCNQ1 (0.56) | KCNQ1HCRTR1HCRTR2POLBKMT2A | |
| SCHEMBL1383477 | 0.90 | KCNQ1 (0.56) | KCNQ1HCRTR1HCRTR2POLBKMT2A | |
| SCHEMBL630055 | 0.89 | KCNQ1 (0.47) | KCNQ1HCRTR1HCRTR2POLBKMT2A | |
| SCHEMBL630823 | 0.86 | KCNQ1 (0.49) | KCNQ1HCRTR1HCRTR2POLBBDKRB1 | |
| SCHEMBL630671 | 0.85 | POLB (0.46) | KCNQ1HCRTR1HCRTR2POLBKMT2A | |
| SCHEMBL631181 | 0.85 | LMNA (0.44) | KCNQ1HCRTR1HCRTR2POLBKMT2A | |
| SCHEMBL631050 | 0.84 | KCNQ1 (0.47) | KCNQ1HCRTR1HCRTR2KMT2ABDKRB1 | |
| SCHEMBL631034 | 0.83 | KCNQ1 (0.44) | KCNQ1HCRTR1HCRTR2POLBKMT2A | |
| SCHEMBL630231 | 0.83 | EPHX2 (0.44) | POLBKMT2ABDKRB1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-B1 | FKBP-binding composition and pharmaceutical use thereof | AVENTIS PHARMA INC (US) | 2012-02-22 | — | — | EP | claimed |