Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308347 | 0.89 | ALOX5AP (0.47) | ALOX5APTSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL6309829 | 0.89 | ALOX5AP (0.51) | ALOX5APALDH1A1 | |
| SCHEMBL6313957 | 0.87 | LMNA (0.48) | ALOX5APTSHRCA2MEN1ALDH1A1 | |
| SCHEMBL6313867 | 0.84 | ALOX5AP (0.52) | ALOX5AP | |
| SCHEMBL6308521 | 0.82 | ALDH1A1 (0.60) | DHFRMEN1ALDH1A1KMT2A | |
| SCHEMBL6313928 | 0.81 | DHFR (0.41) | DHFRTSHR | |
| SCHEMBL6306970 | 0.80 | ALDH1A1 (0.61) | DHFRMEN1ALDH1A1KMT2A | |
| SCHEMBL6308411 | 0.80 | DHFR (0.49) | DHFR | |
| SCHEMBL6315021 | 0.80 | ALDH1A1 (0.63) | DHFRMEN1ALDH1A1KMT2A | |
| SCHEMBL6306974 | 0.80 | ALDH1A1 (0.54) | DHFRMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |