Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | F11 | P03951 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313867 | 0.90 | ALOX5AP (0.52) | ALOX5APCYP2C19 | |
| SCHEMBL6308407 | 0.89 | DHFR (0.47) | ALOX5APALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL6309829 | 0.89 | ALOX5AP (0.51) | ALOX5APALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL6313957 | 0.87 | LMNA (0.48) | ALOX5APALDH1A1LMNARECQLSMN1; SMN2 | |
| SCHEMBL6309036 | 0.78 | ALDH1A1 (0.48) | ALDH1A1LMNARECQLSMN1; SMN2MEN1 | |
| SCHEMBL6309810 | 0.78 | ALDH1A1 (0.76) | RAB9APOLBALDH1A1LMNARECQL | |
| SCHEMBL6308352 | 0.77 | PDE4A (0.59) | RAB9APOLBALDH1A1LMNARECQL | |
| SCHEMBL6308509 | 0.76 | ALDH1A1 (0.65) | RAB9AALDH1A1LMNARECQLSMN1; SMN2 | |
| SCHEMBL6313988 | 0.76 | ALDH1A1 (0.55) | RAB9APOLBALDH1A1LMNARECQL | |
| SCHEMBL6307774 | 0.76 | ALDH1A1 (0.78) | RAB9AALDH1A1LMNARECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |