Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.52 |
| ▸ | KIF11 | P52732 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309829 | 0.93 | ALOX5AP (0.51) | ALOX5APKIF11CYP3A4MAP1LC3BCYP2C19 | |
| SCHEMBL6308347 | 0.90 | ALOX5AP (0.47) | ALOX5APCYP2C19 | |
| SCHEMBL6308407 | 0.84 | DHFR (0.47) | ALOX5AP | |
| SCHEMBL6307633 | 0.82 | EGFR (0.55) | ALOX5APKIF11CYP3A4MAP1LC3BCYP2C19 | |
| SCHEMBL6313957 | 0.82 | LMNA (0.48) | ALOX5APCYP3A4CYP2C19 | |
| SCHEMBL4620734 | 0.81 | KIF11 (0.57) | ALOX5APKIF11CYP3A4MAP1LC3BCYP2C19 | |
| SCHEMBL6308313 | 0.81 | EGFR (0.69) | KIF11CYP2C19EGFR | |
| SCHEMBL4519529 | 0.80 | KIF11 (0.56) | ALOX5APKIF11CYP3A4MAP1LC3BCYP2C19 | |
| SCHEMBL5648396 | 0.80 | KIF11 (0.56) | ALOX5APKIF11CYP3A4MAP1LC3BCYP2C19 | |
| SCHEMBL4283747 | 0.80 | KIF11 (0.56) | ALOX5APKIF11CYP3A4MAP1LC3BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |