Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747422 | 0.88 | HSD11B1 (0.51) | HSD11B1S1PR5GRIN2BKDM1AS1PR1 | |
| SCHEMBL6312719 | 0.87 | HSD11B1 (0.43) | HSD11B1CYP3A4CYP2D6ALDH1A1USP2 | |
| SCHEMBL5748184 | 0.82 | HSD11B1 (0.41) | HSD11B1CYP3A4CYP2D6ALDH1A1USP2 | |
| SCHEMBL6335547 | 0.75 | HSD11B1 (0.51) | HSD11B1S1PR5GRIN2BKDM1AS1PR1 | |
| SCHEMBL5747751 | 0.75 | CACNA1G (0.43) | HSD11B1S1PR5GRIN2BS1PR1 | |
| SCHEMBL5746618 | 0.74 | HSD11B1 (0.46) | HSD11B1S1PR5GRIN2BS1PR1FUCA1 | |
| SCHEMBL8102406 | 0.74 | HSD11B1 (0.58) | HSD11B1CYP2D6ALDH1A1S1PR5S1PR1 | |
| SCHEMBL4318880 | 0.74 | HSD11B1 (0.65) | HSD11B1ALDH1A1TSHRS1PR5GRIN2B | |
| SCHEMBL6326368 | 0.74 | HSD11B1 (0.45) | HSD11B1S1PR5GRIN2BS1PR1 | |
| SCHEMBL6316974 | 0.71 | GRIN2B (0.47) | S1PR5GRIN2BS1PR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | TACR2, TACR1, TAC3 | HSD11B1 2277/4885CYP3A4 2058/4885CYP2D6 2419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.