Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744862 | 0.89 | CYP2D6 (0.41) | CACNA1GCACNA1HCACNA1ICYP2D6ALDH1A1 | |
| SCHEMBL6319094 | 0.86 | ALDH1A1 (0.45) | CYP2D6MAPK1KMT2AALDH1A1HTR2C | |
| SCHEMBL6310215 | 0.78 | CACNA1G (0.44) | CACNA1GCACNA1HCACNA1IHTR2C | |
| SCHEMBL6310196 | 0.75 | CACNA1G (0.44) | CACNA1GCACNA1HCACNA1IHTR2C | |
| SCHEMBL5747751 | 0.73 | CACNA1G (0.43) | CACNA1GCACNA1HCACNA1IHTR2C | |
| SCHEMBL6310201 | 0.70 | CACNA1G (0.44) | CACNA1GCACNA1HCACNA1IHTR2C | |
| SCHEMBL5745363 | 0.69 | PARP1 (0.48) | — | |
| SCHEMBL5517077 | 0.68 | HTR2C (0.64) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 | |
| SCHEMBL5517082 | 0.68 | HTR2C (0.64) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 | |
| SCHEMBL10053573 | 0.68 | HTR2C (0.64) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | TACR2, TACR1, TAC3 | CACNA1G 1297/4885CACNA1H 1149/4885CACNA1I 1335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.