Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309596 | 0.86 | CACNA1G (0.43) | ALDH1A1CYP2D6MEN1KMT2AHTR2C | |
| SCHEMBL5744862 | 0.81 | CYP2D6 (0.41) | ALDH1A1CYP2D6TSHRCYP2C9CYP3A4 | |
| SCHEMBL6311540 | 0.76 | CCR5 (0.46) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6316974 | 0.72 | GRIN2B (0.47) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5963519 | 0.71 | PSEN1 (0.45) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19251183 | 0.70 | HTR2C (0.52) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14762185 | 0.70 | AGTR2 (0.50) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5869413 | 0.69 | F2 (0.47) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1820197 | 0.69 | F2 (0.47) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5517077 | 0.69 | HTR2C (0.64) | ALDH1A1SMN1; SMN2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | TACR2, TACR1, TAC3 | ALDH1A1 2855/4885CYP2D6 2419/4885TSHR 975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.