Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 known ✓ | P30411 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23852343 | 0.98 | BDKRB2 (0.40) | HTTBDKRB2L3MBTL1DNM1MCHR1 | |
| Bromide SCHEMBL23852358 | 0.94 | BDKRB2 (0.40) | HTTBDKRB2L3MBTL1DNM1MCHR1 | |
| Iodide SCHEMBL23853413 | 0.94 | HTT (0.39) | HTTBDKRB2L3MBTL1DNM1MCHR1 | |
| Bromide SCHEMBL7611775 | 0.89 | HIF1A (0.47) | HTTDNM1TRAP1ALDH1A1 | |
| Bromide SCHEMBL7196672 | 0.88 | HRH3 (0.39) | HTTBDKRB2L3MBTL1DNM1MCHR1 | |
| Hydrochloric Acid SCHEMBL23038728 | 0.82 | TRAP1 (0.34) | TRAP1 | |
| Hydrochloric Acid SCHEMBL5084888 | 0.82 | HIF1A (0.56) | HTTBDKRB2TRAP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5085298 | 0.82 | HIF1A (0.56) | HTTBDKRB2TRAP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL716757 | 0.82 | HIF1A (0.56) | HTTBDKRB2TRAP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2415697 | 0.82 | HIF1A (0.56) | HTTBDKRB2TRAP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867012-B2 | Determination method of biological component and reagent kit used therefor | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 2005-03-15 | — | — | US | disclosed |
| US-20020119507-A1 | Determination method of biological component and reagent kit used therefor | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 2002-08-29 | — | — | US | disclosed |
| EP-1213358-A2 | Method and kit for the determination of a biological component | Toyo Boseki Kabushiki Kaisha (JP) | 2002-06-12 | — | — | EP | disclosed |
| EP-0402094-B1 | Process for measuring body fluid components | WAKO PURE CHEM IND LTD (JP) | 1996-08-28 | — | — | EP | disclosed |
| US-5384248-A | Process for measuring an analyte with an oxidase and an oxidizable color reagent and surfactants | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| EP-0402094-A2 | Process for measuring body fluid components | WAKO PURE CHEMICAL INDUSTRIES LTD (JP) | 1990-12-12 | — | — | EP | disclosed |