Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059428 | 0.84 | MAPK1 (0.54) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6575685 | 0.82 | CA12 (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1457515 | 0.77 | MAPT (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL12394100 | 0.77 | L3MBTL1 (0.52) | ESR1LMNACYP1A2CYP3A4STS | |
| SCHEMBL659139 | 0.75 | CA12 (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL29800427 | 0.75 | CA12 (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL811649 | 0.75 | CA12 (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3376117 | 0.75 | CA12 (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1091973 | 0.75 | MAPT (0.55) | CA12CA1CA2CA7CA9 | |
| SCHEMBL152572 | 0.73 | CA12 (0.59) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050176773-A1 | Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and method for their use | AGOURON PHARMACEUTICALS, INC. | 2005-08-11 | — | — | US | disclosed |
| US-20050038078-A1 | Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2005-02-17 | — | — | US | disclosed |
| US-20050026966-A1 | Process and chiral amine intermediates useful for preparation of antiproliferative 2,4-diaminothiazole amide compounds | AGOURON PHARMACEUTICALS, INC. | 2005-02-03 | — | — | US | disclosed |
| US-20050026966-A1 | Process and chiral amine intermediates useful for preparation of antiproliferative 2,4-diaminothiazole amide compounds | AGOURON PHARMACEUTICALS, INC. | 2005-02-03 | — | — | US | disclosed |
| US-20050026966-A1 | Process and chiral amine intermediates useful for preparation of antiproliferative 2,4-diaminothiazole amide compounds | AGOURON PHARMACEUTICALS, INC. | 2005-02-03 | — | — | US | disclosed |
| WO-2004014904-A1 | ANTIPROLIFERATIVE 2-(HETEROARYL)-AMINOTHIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE | PFIZER INC. (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176773-A1 | Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and method for their use | CDK2, MKI67, CCNK | CA12 4734/4885CA1 4633/4885CA2 2605/4885 |
| US-20050038078-A1 | Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and methods for their use | CDK2, CCNK, MKI67 | CA12 4749/4885CA1 4617/4885CA2 2662/4885 |
| US-20050026966-A1 | Process and chiral amine intermediates useful for preparation of antiproliferative 2,4-diaminothiazole amide compounds | DDC, TK1, AADAT | CA12 3626/4885CA1 2753/4885CA2 1960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.