Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 8/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 2/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13093264 | 0.90 | SLC6A2 (0.50) | QDPRSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL2707542 | 0.81 | SLC18A3 (0.59) | QDPRHTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL240518 | 0.81 | HTR2C (0.62) | QDPRHTR2CSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL29688235 | 0.80 | SLC18A3 (0.57) | QDPRHTR2CSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL2799671 | 0.80 | SLC18A3 (0.57) | QDPRHTR2CSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL377800 | 0.79 | HTR2C (0.63) | QDPRHTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7968419 | 0.79 | QDPR (0.61) | QDPRHTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7966782 | 0.79 | HTR2C (0.64) | QDPRHTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL378006 | 0.78 | HTR2C (0.62) | QDPRHTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19003055 | 0.78 | MPO (0.46) | QDPRHTR2CSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844344-B2 | Benzofuran derivatives | ELI LILLY AND COMPANY (US) | 2005-01-18 | — | — | US | disclosed |
| US-6784180-B2 | INHIBITING THE REUPTAKE OF SEROTONIN AND ANTAGONIZING THE 5-HT1A RECEPTOR; AS ANTIDEPRESSANT OR TO POTENTIATE EFFECTS OF ANOTHER SSRI | ELI LILLY AND COMPANY | 2004-08-31 | — | — | US | disclosed |
| EP-1250336-B1 | PIPERIDINE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2004-05-12 | — | — | EP | disclosed |
| US-20030232833-A1 | Benzofuran derivatives | ELI LILLY AND COMPANY | 2003-12-18 | — | — | US | disclosed |
| US-20030225281-A1 | Piperidines derivatives and their use as serotonin receptor antagonists | ELI LILLY AND COMPANY | 2003-12-04 | — | — | US | disclosed |
| EP-1250336-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-1246822-A1 | BENZOFURAN DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001046179-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |
| WO-2001046177-A1 | BENZOFURAN DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225281-A1 | Piperidines derivatives and their use as serotonin receptor antagonists | HTR1A, HTR1D, HTR5A | QDPR 156/4885HTR2C 7/4885SLC6A2 123/4885 |
| US-20030232833-A1 | Benzofuran derivatives | BRD1, BPTF, HTR1F | QDPR 571/4885HTR2C 52/4885SLC6A2 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.