Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 6/20 | 0.49 |
| ▸ | IGF1R | P08069 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314480 | 0.89 | IGF1R (0.46) | ALPLIGF1RLMNASMN1; SMN2PIK3CA | |
| SCHEMBL6311387 | 0.86 | IGF1R (0.47) | ALPLIGF1RLMNASMN1; SMN2PIK3CA | |
| SCHEMBL6318985 | 0.85 | PIK3CA (0.46) | ALPLIGF1RSMN1; SMN2PIK3CATNF | |
| SCHEMBL6313711 | 0.82 | PIK3CA (0.41) | ALPLLMNASMN1; SMN2PIK3CAKDM4E | |
| SCHEMBL6313459 | 0.82 | PIK3CA (0.41) | ALPLLMNASMN1; SMN2PIK3CAKDM4E | |
| SCHEMBL6313731 | 0.78 | PIK3CA (0.41) | ALPLIGF1RPIK3CATNFADORA2A | |
| SCHEMBL6318862 | 0.77 | DHFR (0.56) | IGF1RPIK3CATNFKDM4EADORA2A | |
| SCHEMBL6315310 | 0.76 | ADORA1 (0.45) | ALPLIGF1RLMNASMN1; SMN2PIK3CA | |
| SCHEMBL6315288 | 0.74 | PDGFRB (0.49) | SMN1; SMN2PIK3CATNFKDM4EALDH1A1 | |
| SCHEMBL6313077 | 0.74 | PIK3CA (0.47) | IGF1RPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |