Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 4/20 | 0.44 |
| ▸ | ALPL | P05186 | 7/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | BCL6 | P41182 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313033 | 0.86 | ALPL (0.42) | ADORA1IGF1RALPLDHFRMEN1 | |
| SCHEMBL6317900 | 0.82 | IMPDH2 (0.52) | — | |
| SCHEMBL6318862 | 0.82 | DHFR (0.56) | ADORA1IGF1RDHFRPIK3CAKDR | |
| SCHEMBL6313704 | 0.81 | IGF1R (0.59) | IGF1RPIK3CA | |
| SCHEMBL6312667 | 0.81 | ADORA1 (0.40) | ADORA1IGF1RALPLMEN1KMT2A | |
| SCHEMBL6311387 | 0.81 | IGF1R (0.47) | IGF1RALPLPIK3CAEGFRINSR | |
| SCHEMBL6318945 | 0.79 | TNF (0.44) | ALPLDHFRMEN1KMT2APIK3CA | |
| SCHEMBL6312312 | 0.78 | IGF1R (0.49) | ADORA1IGF1RPIK3CAEGFRINSR | |
| SCHEMBL6313731 | 0.78 | PIK3CA (0.41) | ADORA1IGF1RALPLDHFRKMT2A | |
| SCHEMBL6315288 | 0.77 | PDGFRB (0.49) | ADORA1PIK3CAKDRBCL6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |