Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 3/20 | 0.44 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.43 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | BCL6 | P41182 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313634 | 0.85 | ALPL (0.49) | PIK3CATNFALPLIGF1RMAPT | |
| SCHEMBL6311387 | 0.82 | IGF1R (0.47) | PIK3CATNFALPLIGF1RKDR | |
| SCHEMBL6314480 | 0.78 | IGF1R (0.46) | PIK3CATNFALPLIGF1RBCL6 | |
| SCHEMBL6315288 | 0.76 | PDGFRB (0.49) | PIK3CATNFBCL6POLBKDR | |
| SCHEMBL6318862 | 0.76 | DHFR (0.56) | PIK3CATNFIGF1RBCL6KDR | |
| SCHEMBL6318945 | 0.75 | TNF (0.44) | PIK3CATNFALPLMEN1KMT2A | |
| SCHEMBL6317775 | 0.75 | BCL6 (0.42) | PIK3CATNFALPLMEN1KMT2A | |
| SCHEMBL6314083 | 0.74 | BCL6 (0.44) | PIK3CATNFALPLMEN1KMT2A | |
| SCHEMBL6315310 | 0.73 | ADORA1 (0.45) | PIK3CATNFALPLIGF1RMEN1 | |
| SCHEMBL6313731 | 0.72 | PIK3CA (0.41) | PIK3CATNFALPLIGF1RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |