Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 12/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 11/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6311479 | 0.88 | NFE2L2 (0.58) | NFE2L2KEAP1MEN1KMT2ASPR | |
| SCHEMBL6314912 | 0.83 | ALDH1A1 (0.50) | MEN1KMT2AHPGDNPSR1HSD17B10 | |
| Hydrochloric Acid SCHEMBL6314825 | 0.83 | SLC9A1 (0.58) | NFE2L2KEAP1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6314622 | 0.83 | KEAP1 (0.53) | NFE2L2KEAP1MEN1KMT2ASPR | |
| Hydrochloric Acid SCHEMBL6314820 | 0.82 | CNR1 (0.41) | NFE2L2KEAP1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6319867 | 0.82 | KEAP1 (0.58) | NFE2L2KEAP1MEN1KMT2ASPR | |
| SCHEMBL6313750 | 0.82 | MEN1 (0.69) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL6320699 | 0.81 | KEAP1 (0.51) | NFE2L2KEAP1MEN1KMT2ASPR | |
| SCHEMBL6320899 | 0.81 | KEAP1 (0.51) | NFE2L2KEAP1MEN1KMT2AUSP2 | |
| SCHEMBL6320853 | 0.81 | KEAP1 (0.50) | NFE2L2KEAP1MEN1KMT2ASPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974813-B2 | N-[(substituted five-membered di-or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia | WARNER-LAMBERT COMPANY (US) | 2005-12-13 | — | — | US | disclosed |
| US-20030149043-A1 | N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia | PFIZER INC. | 2003-08-07 | — | — | US | disclosed |
| US-6492401-B1 | SODIUM HYDROGEN EXCHANGER TYPE 1 INHIBITORS; REDUCING PERIOPERATIVE MYOCARDIAL TISSUE DAMAGE | PFIZER, INC. | 2002-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149043-A1 | N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia | NHERF1, SLC28A1, TNNI3 | NFE2L2 450/4885KEAP1 313/4885MEN1 4475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.