Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028785 | 0.73 | CREBBP (0.34) | NNMTCREBBPMEN1KMT2AKDM4E | |
| SCHEMBL20023207 | 0.68 | KDM4E (0.35) | NNMTCREBBPMEN1KMT2AKDM4E | |
| SCHEMBL6314154 | 0.67 | KDM4E (0.36) | NNMTMEN1KMT2AKDM4EALOX15 | |
| SCHEMBL14283938 | 0.66 | ALDH1A1 (0.46) | MEN1KMT2AKDM4EALOX15HSD17B10 | |
| SCHEMBL6315508 | 0.64 | HTT (0.34) | KMT2AACHEALDH1A1 | |
| SCHEMBL14619954 | 0.64 | CREBBP (0.37) | NNMTCREBBPMEN1KMT2AKDM4E | |
| SCHEMBL14234586 | 0.63 | MAPT (0.39) | NNMTCREBBPKDM4EALOX15HSD17B10 | |
| SCHEMBL9507295 | 0.62 | ACHE (0.40) | MEN1KMT2AKDM4EALOX15HSD17B10 | |
| SCHEMBL9336520 | 0.60 | BRD4 (0.34) | NNMTCREBBPMEN1KMT2AALDH1A1 | |
| SCHEMBL3919249 | 0.60 | CREBBP (0.40) | CREBBPMEN1KMT2AHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |