Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6322510 | 0.71 | ALDH1A1 (0.41) | HTTALDH1A1LMNA | |
| SCHEMBL6314154 | 0.67 | KDM4E (0.36) | HTTALDH1A1LMNAKMT2AACHE | |
| SCHEMBL14283938 | 0.66 | ALDH1A1 (0.46) | HTTALDH1A1LMNAKMT2AACHE | |
| SCHEMBL6315518 | 0.64 | NNMT (0.35) | ALDH1A1KMT2AACHE | |
| SCHEMBL9507295 | 0.62 | ACHE (0.40) | HTTALDH1A1LMNAKMT2AACHE | |
| SCHEMBL23856899 | 0.61 | ALOX5 (0.34) | HTTALDH1A1ACHE | |
| SCHEMBL6028967 | 0.60 | HTT (0.41) | HTTALDH1A1LMNAKMT2A | |
| SCHEMBL2484255 | 0.59 | ALOX5 (0.48) | LMNA | |
| SCHEMBL21872803 | 0.58 | HTT (0.32) | HTT | |
| SCHEMBL18920124 | 0.58 | PNMT (0.39) | LMNAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1211253-A1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |