Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.50 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8268319 | 0.88 | TDP1 (0.54) | TDP1PKMFKBP1AALDH1A1LMNA | |
| SCHEMBL13206975 | 0.88 | TDP1 (0.54) | TDP1PKMFKBP1AALDH1A1LMNA | |
| SCHEMBL630786 | 0.85 | TDP1 (0.46) | TDP1PKMFKBP1AALDH1A1LMNA | |
| SCHEMBL1384829 | 0.82 | KMT2A (0.50) | TDP1PKMFKBP1AALDH1A1LMNA | |
| SCHEMBL1383977 | 0.82 | KMT2A (0.50) | TDP1PKMFKBP1AALDH1A1LMNA | |
| SCHEMBL1381494 | 0.81 | FKBP1A (0.55) | TDP1PKMFKBP1AALDH1A1LMNA | |
| SCHEMBL630237 | 0.81 | ITGB1 (0.63) | TDP1PKMFKBP1AALDH1A1LMNA | |
| SCHEMBL1383454 | 0.81 | ITGB1 (0.63) | TDP1PKMFKBP1AALDH1A1LMNA | |
| SCHEMBL27405503 | 0.77 | MMP2 (0.63) | TDP1PKMFKBP1AALDH1A1LMNA | |
| SCHEMBL21281608 | 0.77 | MMP2 (0.63) | TDP1PKMFKBP1AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-B1 | FKBP-binding composition and pharmaceutical use thereof | AVENTIS PHARMA INC (US) | 2012-02-22 | — | — | EP | disclosed |