⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6319419 | 1.00 | — | — | |
| SCHEMBL14523968 | 0.81 | TGM2 (0.30) | — | |
| SCHEMBL6322693 | 0.79 | — | — | |
| SCHEMBL3908663 | 0.79 | TGM2 (0.32) | — | |
| SCHEMBL5008366 | 0.79 | — | — | |
| SCHEMBL6103697 | 0.78 | TGM2 (0.32) | — | |
| SCHEMBL14523965 | 0.76 | EPHX2 (0.34) | — | |
| SCHEMBL3977333 | 0.76 | TGM2 (0.30) | — | |
| SCHEMBL3916186 | 0.70 | CYP17A1 (0.39) | — | |
| SCHEMBL6324165 | 0.70 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | claimed |
| US-6864252-B2 | Hydrazinyl and nitrogen oxide pyrazoles | PFIZER, INC. (US) | 2005-03-08 | — | — | US | claimed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | claimed |
| US-20030134850-A1 | Hydrazinyl and nitrogen oxide pyrazoles | PFIZER INC. | 2003-07-17 | — | — | US | claimed |
| EP-1308158-A1 | Sulfonylaryl- and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors | Pfizer Productors Inc. (US) | 2003-05-07 | — | — | EP | claimed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | claimed |
| US-20050282985-A1 | FLUORINE-ATOM-CONTAINING POLYMERIZABLE UNSATURATED-MONOMER, FLUORINE-ATOM-CONTAINING POLYMERIC COMPOUND AND PHOTORESIST RESIN COMPOSITION | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2005-12-22 | — | — | US | disclosed |
| US-6864252-B2 | Hydrazinyl and nitrogen oxide pyrazoles | PFIZER, INC. (US) | 2005-03-08 | — | — | US | disclosed |
| US-20030134850-A1 | Hydrazinyl and nitrogen oxide pyrazoles | PFIZER INC. | 2003-07-17 | — | — | US | disclosed |
| EP-1308158-A1 | Sulfonylaryl- and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors | Pfizer Productors Inc. (US) | 2003-05-07 | — | — | EP | disclosed |