Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | C1S | P09871 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28417343 | 0.84 | TPMT (0.55) | TPMTSMN1; SMN2POLBACHETSHR | |
| SCHEMBL6312819 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2POLBACHELMNATSHR | |
| SCHEMBL6314224 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2POLBACHELMNATSHR | |
| SCHEMBL336773 | 0.79 | CES2 (0.65) | SMN1; SMN2CES2CES1POLBACHE | |
| SCHEMBL60996 | 0.79 | CES2 (0.65) | SMN1; SMN2CES2CES1POLBACHE | |
| SCHEMBL17295886 | 0.78 | CES2 (0.41) | SMN1; SMN2CES2CES1ACHELMNA | |
| SCHEMBL143 | 0.78 | CES1 (0.53) | SMN1; SMN2CES2CES1POLBLMNA | |
| SCHEMBL27969098 | 0.76 | MEN1 (0.50) | TPMTSMN1; SMN2CES2CES1POLB | |
| SCHEMBL6460085 | 0.76 | KMT2A (0.40) | SMN1; SMN2CES2CES1ACHELMNA | |
| SCHEMBL14286947 | 0.76 | ALDH1A1 (0.64) | TPMTSMN1; SMN2CES2CES1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924301-B1 | Composition for treating or preventing arrhythmia | SHIONOGI & CO., LTD. (JP) | 2005-08-02 | — | — | US | disclosed |
| EP-1240906-A1 | PREVENTIVES OR REMEDIES FOR ARRHYTHMIA | SHIONOGI & CO., LTD. (JP) | 2002-09-18 | — | — | EP | disclosed |