Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4093253 | 0.85 | MAOA (0.52) | MAOAMAOBCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3643464 | 0.85 | MEN1 (0.47) | MAOAMAOBCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5441304 | 0.82 | MAOA (0.58) | MAOAMAOBCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL15891123 | 0.80 | ALDH1A1 (0.39) | MAOAMAOBCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL15891114 | 0.80 | ALDH1A1 (0.39) | MAOAMAOBCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7774904 | 0.80 | MAOA (0.56) | MAOAMAOBCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL31613229 | 0.80 | MAOA (0.56) | MAOAMAOBCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL19990170 | 0.80 | MAOA (0.56) | MAOAMAOBCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27498655 | 0.79 | L3MBTL1 (0.49) | MAOBNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL10487337 | 0.78 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10226660-A | — | — | None | — | — | JP | disclosed |
| JP-10218826-A | — | — | None | — | — | JP | disclosed |
| JP-10182568-A | — | — | None | — | — | JP | disclosed |
| CN-110483366-B | Indole compound and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-09-16 | — | — | CN | disclosed |
| US-8586617-B2 | Aminomethyl-4-imidazoles | HOFFMANN-LA ROCHE INC. (US) | 2013-11-19 | — | — | US | disclosed |
| CN-101528710-B | Aminomethyl-4-imidazoles | HOFFMANN LA ROCHE | 2012-11-07 | — | — | CN | disclosed |
| EP-2076497-B1 | AMINOMETHYL-4-IMIDAZOLES | HOFFMANN LA ROCHE (CH) | 2012-02-22 | — | — | EP | disclosed |
| EP-2076497-A1 | AMINOMETHYL-4-IMIDAZOLES | F. Hoffmann-Roche AG (CH) | 2009-07-08 | — | — | EP | disclosed |
| US-20080119535-A1 | AMINOMETHYL-4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-22 | — | — | US | disclosed |
| WO-2008046757-A1 | AMINOMETHYL-4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |
| JP-H10226660-A | PRODUCTION OF 1-FLUORO-2-PHENOXY-4-(2-PROPENYL)BENZENE | SUMITOMO CHEM CO LTD | 1998-08-25 | — | — | JP | disclosed |
| JP-H10218826-A | PRODUCTION OF 4-FLUORO-3-PHENOXYBROMOBENZENE | SUMITOMO CHEM CO LTD | 1998-08-18 | — | — | JP | disclosed |
| JP-H10182568-A | 4-FLUORO-3-PHENOXYANILINE AND ITS PRODUCTION | SUMITOMO CHEM CO LTD | 1998-07-07 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119535-A1 | AMINOMETHYL-4-IMIDAZOLES | INMT, HTR4, MC4R | MAOA 148/4885MAOB 124/4885CYP1A2 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.